http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2331519-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_767d0d7a00b5d921c9324ee92aa9f0ca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 2004-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5045f7a00e1f9199e145b987932a56de http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c0d10887df2f99ab6083d7c45bc67bf2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_485518ae0f2960478836fac35b4a84eb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bdbb300690ef16182e0c2e4dd411d50f |
| publicationDate | 2010-01-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2331519-T3 |
| titleOfInvention | PIRROLO-DIHYDROISOQUINOLINE DERIVATIVES AS PDE INHIBITORS10. |
| abstract | Compounds that inhibit PDE10, or salts thereof, which comprise a structure element of formula X ** (See formula) ** in which R1 is halogen, nitro, C1-4 alkyl, C1-4 alkoxy, C1-4 alkoxy -C2-4 alkoxy, C3-7 cycloalkoxy or C3-7 cycloalkoxy, R2 is C1-4 alkoxy, R3 is hydrogen or C1-4 alkoxy, R4 is hydrogen, R41 is hydrogen, R5 is hydrogen or C1-4 alkyl , and R51 is hydrogen or C1-4 alkyl, or R4 is hydrogen, R41 is hydrogen, R5 is C1-4 alkoxycarbonyl, and R51 is hydrogen, or R4 is hydrogen, R41 is hydrogen, R5 is cyano, and R51 is hydrogen, or R4 and R5 together form a C3-4 alkylene bridge, and R41 and R51 are both hydrogen, R6 is C1-6 alkyl, amino, formyl, or C1-4 alkyl substituted with R61, wherein R61 is alkoxy C1-4-carbonyl, carboxyl, C1-4 alkoxy, hydroxyl, halogen or -N (R611) R612, wherein R611 is hydrogen, C1-4 alkyl, C3-7 cycloalkyl or C3-7 cycloalkyl-C1-4 alkyl , and R612 is hydrogen or C1-4 alkyl, or R611 and R612, together and including the nitrogen atom to which they are attached, form a radical Het1, in which Het1 is a saturated 5- to 7-membered heterocyclic ring radical comprising a nitrogen atom, to which R611 and R612 are attached, and, optionally, an additional heteroatom selected from a group consisting of nitrogen, oxygen and sulfur, and optionally substituted with R613 in an annular nitrogen atom, wherein R613 is C1-4 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl-C1-4 alkyl, hydroxy-C2-4 alkyl, C1-4 alkoxy-C2-4 alkyl, aminoC2-4 alkyl, mono- or di-C1-4 alkyl-amino-C2-4 alkyl, formyl, pyridyl or pyrimidinyl, R8 is cyano , or -C (O) -OR9, wherein R9 is C1-4 alkyl; with the proviso that, when R8 is -C (O) -OR9, where R9 is C1-4 alkyl, then R5 is different from hydrogen; as an integral part of the overall structure of said compounds. |
| priorityDate | 2003-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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