http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2331144-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D498-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-424 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D498-04 |
| filingDate | 2005-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_18faf4571fa14b1492f833393963969c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be75b6a8d70cf1fc4253f49ce77bcfdc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_060cac5aad04fee9165c9c4e9b9bb538 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e66bc1fa37a0c5c795df96ad9b51594e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2175a05f888e31dd23de6e1cc4c14a9 |
| publicationDate | 2009-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2331144-T3 |
| titleOfInvention | ISOXAZOLINE-INDOL DERIVATIVES WITH IMPROVED ANTIPSYTICAL AND ANSIOLITIC ACTIVITY. |
| abstract | A compound according to the general formula (I) ** (See formula) ** a pharmaceutically acceptable acid or base addition salt thereof, a stereochemically isomeric form thereof or an N-oxide form thereof, wherein : X is CH2; NR4; S or O; wherein R4 is selected from the group of hydrogen, alkyl, Ar, Ar-alkyl, alkylcarbonyl, alkyloxycarbonyl and mono- and di (alkyl) -aminocarbonyl; V is S; O or NR5, wherein R5 is selected from the group of hydrogen and alkyl; or R5 is a covalent bond between nitrogen and the residue (CH2) n; R1 and R2 are each independently selected from the hydrogen group; halo; hydroxy; Not me; I rent; Ar; heteroaryl; cyano; nitro; mono- and di (alkyl) amino; mono- and di (Ar) amino; mono- and di (heteroaryl) amino; mono- and di (alkylcarbonyl) -amino; mono- and di (Ar-carbonyl) amino; mono- and di (heteroarylcarbonyl) amino; mono- and di (heteroaryl-alkyl) amino; alkyloxy; alkylcarbonyloxy; Ar-carbonyloxy; heteroarylcarbonyloxy; alkyloxyalkyloxy; alkyloxyalkyloxyalkyloxy; alkylcarbonyloxyalkyloxy; alkyloxyalkylcarbonyloxyalkyloxy and mono- and di (alkyl) aminocarbonyloxyalkyloxy; or R1 and R2 can together form a bivalent radical of the formula -OCH2O-; -OCH2CH2O- or -OCH2CH2CH2O-; R3 is selected from the group of hydrogen; hydroxy; Not me; nitro; cyano; halo; I rent; alkyloxy; alkyloxyalkyloxy; alkyloxyalkyloxyalkyloxy; Ar; mono- and di (alkyl) aminocarbonylamino; mono- and di (Ar) aminocarbonylamino; mono- and di (alkyloxycarbonylcarbonyl) amino; mono- and di (di (alkylcarbonyl) amino; mono- and di (alkyloxyalkylcarbonyl) -amino and mono- and di (alkylsulfonyl) amino; q is an integer equal to zero; 1 or 2; (CH2) m is a covalent bond or a linear hydrocarbon chain of m carbon atoms, m being an integer equal to 1, 2 or 3; (CH2) n is a covalent bond or a linear hydrocarbon chain of n carbon atoms, n being a number integer equal to 1, 2, 3 or 4; Pir is a bivalent radical according to any one of formulas (IIa), (IIb) or (IIc), each radical being optionally substituted with p radicals R6, where: * * (See formula) ** each R6 is independently selected from each other from the group of hydrogen; hydroxy; amino; nitro; cyano; halo and alkyl; p is an integer equal to zero; 1 or 2; Ar is phenyl or naphthyl; each radical being optionally substituted with one or more halo, cyano, oxo, hydroxy, alkyl, formyl, alkyloxy or amino radicals; heteroaryl represents a heteroc radical monocyclic cyclic selected from the azetidinyl group; pyrrolidinyl; dioxolyl; imidazolidinyl; pyrazolidinyl; piperidinyl; homopiperidinyl; dioxyl; morpholinyl; dithianyl; thiomorpholinyl; piperazinyl; imidazolidinyl; tetrahydrofuranyl; 2H-pyrrolyl; pyrrolinyl, imidazolinyl; pyrazolinyl; pyrrolyl; imidazolyl; pyrazolyl; triazolyl; furanyl; thienyl; oxazolyl; isoxazolyl; thiazolyl; thiadiazolyl; isothiazolyl; pyridinyl; pyrimidinyl; pyrazinyl; pyridazinyl and triazinyl; each heterocyclic radical is optionally substituted with one or more radicals selected from the group of alkyl, phenyl, phenyl substituted with alkyl, benzyl, halo, cyano, oxo, hydroxy, formyl, alkyloxy, alkylcarbonyl, tetrahydrofurylcarbonyl and amino; and alkyl represents a linear or branched saturated hydrocarbon radical having 1 to 6 carbon atoms or a cyclic saturated hydrocarbon radical having 3 to 6 carbon atoms, each hydrocarbon radical being optionally substituted with one or more halo, cyano radicals, oxo, hydroxy, formyl or amino. |
| priorityDate | 2004-11-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 150.