| abstract |
A compound of formula (IB): ** (See formula) ** where: Ra and Rb together with the carbon atoms of the pyrimidine ring to which they are attached form a 5-membered fused carbocyclic ring; R2CH2X is 4-fluorobenzylthio; R3 is C (1-3) alkyl substituted with NR8R9; or o R3 is Het-C (0-2) alkyl wherein Het is a 5- to 7-membered heterocyclyl ring comprising N and where N can be substituted with C (1-6) alkyl. R4 and R5 form a 4- (4-trifluoromethylphenyl) phenyl group; R8 and R9, which may be the same or different, are each selected from hydrogen or C (1-6) alkyl; and X is S; or one of its pharmaceutically acceptable salts. |