http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2328824-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_938a6d7a15cbc93a74abe1953eb25d47 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D263-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-422 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-56 |
| filingDate | 2004-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d6d9731ecb52fe8f8f1d8b063a9b168 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87bbf8fa1680a272aa76c12572130cab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a99624bad763b561c82b5960d04185fe http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_507b226db040144eaf921d8e948c5576 |
| publicationDate | 2009-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2328824-T3 |
| titleOfInvention | USEFUL TIAZOLS AND OXAZOLES AS MODULATORS OF CONNECTORS OF CASETE TYPE FROM UNION TO ATP. |
| abstract | In vitro use of a compound of formula (I): ** (See formula) ** or its pharmaceutically acceptable salt, wherein X is O or S; R1 is hydrogen, or is a 3-8 membered saturated, partially unsaturated, or fully unsaturated monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a saturated 8-12 membered bicyclic ring system , partially unsaturated, or fully unsaturated having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, in which R1 is optionally substituted at one or more carbon or nitrogen atoms with x independent occurrences of -QRX; where x is 0-5; where Q is a bond or is a C1-C6 alkylidene chain in which up to two methylene units of Q are optionally and independently substituted with -CO-, -CO2-, -COCO-, -CONR-, -OCONR- , -NRNR-, -NRNRCO-, -NRCO-, -NRCO2-, -NRCONR-, -SO-, -SO2-, -NRSO2-, -SO2NR-, -NRSO2NR-, -O-, -S-; or -NR-; and each occurrence of RX is independently selected from R '', halogen, NO2, or CN, or -QRX is = O, = S, or = NR ''; Z is a bond or is an optionally substituted C1-C4 alkylidene chain, in which up to two methylene units of the chain are optionally and independently substituted with -NR-, -S-, -O-, -SO2NR- -NRSO2- , -SO2-, or -CO-; each occurrence of R is independently hydrogen or an optionally substituted C1-C6 aliphatic group; and each occurrence of R '' is independently hydrogen or an optionally substituted C1-C6 aliphatic group, a saturated, partially unsaturated, or totally unsaturated 3-8 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a saturated, partially unsaturated, or totally unsaturated 8-12-membered bicyclic ring system having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or R and R '', two occurrences of R, or two occurrences of R '', are taken together with the atom or atoms to which they are attached to form a saturated 3-12-membered monocyclic or bicyclic ring, partially unsaturated, or fully unsaturated, optionally substituted, having 0-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; R2 is halogen, -CN, -NO2, or -TqR; R3 is UmR '' and R4 is VpCy1. wherein each m, p, and q is independently 0 or 1, and each U, V, and T is independently an optionally substituted C1-4 alkylidene chain, in which up to two methylene units of the chain are optionally and independently substituted with -CO-, -CO2-, -COCO-, -CONR-, -OCONR-, -NRNR-, -NRNRCO-, -NRCO-, -NRCO2-, -NRCONR-, -SO-, -SO2-, - NRSO2-, -SO2NR-, -NRSO2NR-, -O-, -S-; or -NR-; Cy1 is a saturated, partially unsaturated, or totally unsaturated 3-8 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a saturated, partially unsaturated 8-12 bicyclic ring system, or fully unsaturated having 0-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, in which Cy1 is optionally substituted at one or more carbon or nitrogen atoms with, and independent occurrences of, -WRW; in which y is 0-5; wherein W is a bond or is a C1-C6 alkylidene chain in which up to two methylene units of W are optionally and independently substituted with -CO-, -CO2-, -COCO-, -CONR-, -OCONR- , -NRNR-, -NRNRCO-, -NRCO-, -NRCO2-, -NRCONR-, -SO-, -SO2-, -NRSO2-, -SO2NR-, -NRSO2NR-, -O-, -S-; or -NR-; and each occurrence of RW is independently selected from R '', halogen, NO2, or CN, or -WRW is = O, = S, or = NR ''; or R3 and R4, taken together with the nitrogen atom to which they are attached form a saturated, partially unsaturated or totally unsaturated, optionally substituted 5, 6 or 7-membered ring, which has the structure: ** (See formula) ** where r is 0, 1 or 2; one of X3, X4, or X5 is CH-Vp-Cy1 or N-Vp-Cy1, and the others of X3, X4, or X5 are CHR '' or NR ''; and each occurrence of X1, when present, and X2 is each independently C (R '') 2, -CO-, or -CS- to modulate the activity of the ABC transporter. |
| priorityDate | 2003-11-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 533.