abstract |
An immunomodulatory polynucleotide comprising: a) 5- (TCG (Nq)) and (X1X2CGX2''X1 '' (CG) p) where N is nucleosides, y = 1, p = 0 or 1, q = 0 , 1 or 2, and z = 2-20, X1 and X1 '' are self-complementary nucleosides, X2 and X2 '' are self-complementary nucleosides, and in which the T of the 5 '' sequence (TCG (Nq )) and is at the 5 '' end of the polynucleotide; and b) a palindromic sequence of at least 8 bases in length in which the palindromic sequence comprises the first (X1X2CGX2''X1 '') of the sequences (X1X2CGX2''X1 '' (CG) p) z. |