http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2328485-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5f7b665fb8f15d0e2b0911539d39f8a2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 |
| filingDate | 2004-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ba599d3b6b284ff08376c5103ef9c3d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47056dff978414cb48dc1c87c0138bce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c92da31969092a365b1fe2337e65caf1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d3e16d20383c971aeaf70be2b8afea6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_12482af85d10263e361f42e67a9c09e8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39a8aff36d090b85a84ddfa4bb8116e3 |
| publicationDate | 2009-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2328485-T3 |
| titleOfInvention | COMBINATION OF ACTIVE PRINCIPLES THAT INCLUDES A COMPOUND AFFORDED BY THE NPY RECEIVER AND A COMPOSITE AFFINED BY THE 5-HT6 RECEIVER. |
| abstract | Combination of active ingredients, characterized in that it comprises: (A) at least one compound with affinity for the neuropeptide receptor Y (NPY) selected from the group consisting of 1,4-disubstituted piperidine compounds of general formula (Ia) in which R 1a, R 2a, R 3a, R 4a are each independently selected from the group consisting of hydrogen, halogen, an aliphatic radical, linear or branched, saturated or unsaturated, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, optionally containing at least one heteroatom as a member of the ring, which may be linked by an optionally at least monosubstituted alkylene group, and / or may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, an aryl radical or optionally at least monosubstituted heteroaryl, which may be optionally linked by an alkylene group to the menu The monosubstituted and / or may be condensed with an optionally at least mono-substituted mono or polycyclic cyclic system, a nitro, cyano, -OR 12a, -O- (C = O) R 13a, - (C = O) -OR 13a , -SR 14a, -SOR 14a, -SO2R 14a, -NH-SO2R 14a, -SO2NH2 and -NR 15a R 16a, R 5a represents hydrogen, a linear or branched aliphatic radical, saturated or unsaturated, optionally at least monosubstituted, or a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, R 6a, R 7a, R 8a, R 9a are each independently selected from the group consisting of hydrogen, a linear or branched aliphatic radical, saturated or unsaturated, optionally at least monosubstituted , a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, optionally containing at least one heteroatom as a ring member, a cyano moiety and a -COOR 17a, A a represents a bridge member -CHR 18a - or -CHR 18a - CH2-, B a represents an alif radical linear or branched, saturated or unsaturated, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, a COOR 19a moiety, a moiety - (C = O) R 20a or a moiety -CH2OR 23a, R 10a represents hydrogen, an aliphatic, linear or branched, saturated or unsaturated radical, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, optionally containing at least one heteroatom as a ring member, or an aryl or heteroaryl radical optionally at least monosubstituted, which may be linked by an optionally at least monosubstituted alkylene group, and / or may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, R 11a represents an aliphatic, linear or branched, saturated or unsaturated radical , optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally and at least monosubstituted, optionally containing at least one heteroatom as a member of the ring, which may be linked by an optionally at least monosubstituted alkylene group, and / or may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, or a optionally at least monosubstituted aryl or heteroaryl radical, which may be linked by an optionally at least monosubstituted alkylene group and / or may be fused to an optionally at least monosubstituted mono or polycyclic cyclic system, or R 10a and R 11a together with the bridge atom nitrogen form a saturated, unsaturated or aromatic heterocyclic ring, optionally at least monosubstituted, which may contain at least one additional heteroatom as a member of the ring and / or may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, R 12a represents hydrogen, an aliphatic radical, linear or branched, sat urate or unsaturated, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, optionally containing at least one heteroatom as a member of the ring, which may be linked by an optionally at least monosubstituted alkylene group, and / or may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, or an optionally at least monosubstituted aryl or heteroaryl radical, which may be linked by an optionally at least monosubstituted alkylene group and / or may be condensed with a mono or polycyclic cyclic system optionally at least monosubstituted, R 13a represents hydrogen, an aliphatic, linear or branched, saturated or unsaturated radical, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, optionally containing at least one heteroatom as a ring member , what p it may be linked by an optionally at least monosubstituted alkylene group, and / or it may be fused to an optionally at least monosubstituted mono or polycyclic cyclic system, or an optionally at least monosubstituted aryl or heteroaryl radical, which may be linked by an optionally alkylene group at least monosubstituted and / or may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, R 14a represents an aliphatic, linear or branched, saturated or unsaturated radical, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at less monosubstituted, optionally containing at least one heteroatom as a ring member, which may be linked by an optionally at least monosubstituted alkylene group, and / or may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, or an aryl radical or heteroaryl optionally to l less monosubstituted, which may be linked by an optionally at least monosubstituted alkylene group and / or may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, R 15a and R 16a are each independently selected from the group consisting of hydrogen , a linear or branched, saturated or unsaturated aliphatic radical, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, optionally containing at least one heteroatom as a ring member, which may be optionally linked by an alkylene group at least monosubstituted and / or may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, or an optionally at least monosubstituted aryl or heteroaryl radical, which may be linked by an optionally at least monosubstituted alkylene group, and / or may be condensed with a cyclic system mo no or optionally at least monosubstituted polycyclic, or R 15a and R 16a together with the nitrogen bridge atom form a saturated, unsaturated or aromatic heterocyclic ring, which may be at least monosubstituted and / or contain at least one additional heteroatom as a ring member , R 17a represents hydrogen, a linear or branched, saturated or unsaturated aliphatic radical, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, optionally containing at least one heteroatom as a ring member or an aryl radical or optionally at least monosubstituted heteroaryl, which may be linked by an optionally at least monosubstituted alkylene group and / or may be fused to an optionally at least monosubstituted mono or polycyclic cyclic system, R 18a represents hydrogen, a linear or branched aliphatic radical, saturated or unsaturated, optionally at least monosubstituted, a ra saturated or unsaturated cycloaliphatic dical, optionally at least monosubstituted, optionally containing at least one heteroatom as a ring member or an optionally at least monosubstituted aryl or heteroaryl radical, which may be linked by an optionally at least monosubstituted alkylene group, and / or may being condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, R 19a represents hydrogen, a linear or branched aliphatic radical, saturated or unsaturated, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, or a radical optionally at least monosubstituted aryl or heteroaryl, which may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, R 20a represents hydrogen, a linear or branched, saturated or unsaturated aliphatic radical, optionally at least monosubstituted, a sat cycloaliphatic radical urate or unsaturated, optionally at least monosubstituted, an optionally at least monosubstituted aryl or heteroaryl radical, which may be condensed with an optionally at least monosubstituted mono or polycyclic cyclic system, or a NR 21a R 22a, R 21a moiety represents hydrogen, a radical linear or branched aliphatic, saturated or unsaturated, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, or an optionally at least monosubstituted aryl or heteroaryl radical, which may be condensed with a mono or polycyclic cyclic system optionally at less monosubstituted, R 22a represents hydrogen, a linear or branched, saturated or unsaturated aliphatic radical, optionally at least monosubstituted, a saturated or unsaturated cycloaliphatic radical, optionally at least monosubstituted, or an optionally at least monosubstituted aryl or heteroaryl radical, which may be condensed with an s mono or polycyclic cyclic system is optionally at least monosubstituted, R 23a represents hydrogen, a radium |
| priorityDate | 2003-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 717.