http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2328405-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cf32b60391b469c41e86c353437f5751 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 |
| filingDate | 2006-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f75ebb4157653b5f24332d445d4c32b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e70b1469857bc5d0ef85e1b0b54ae0f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c81dc3bd55e5dcc2c947524ad0e873ee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8b4e168e4e91d2810da4b3632e293a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4c4107067b310f32e03a6745c4a4c30f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf9ee48e052c674f9b63e7d65bad2114 |
| publicationDate | 2009-11-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2328405-T3 |
| titleOfInvention | PIPERAZINE REPLACED BY 2-AMINOCARBONIL OR DIAZA-CYCLIC COMPOUNDS AS MODULATORS OF THE APOPTOSIS PROTEIN INHIBITOR (IAP). |
| abstract | A Compound of formula (I), ** see formula ** wherein R 1 is a hydrogen atom, or an alkyl, heteroalkyl, alkenyl, heteroalkenyl, alkynyl, heteroalkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl radical, aralkyl or heteroaralkyl, any of which can also be substituted with at least one halogen; R2 is an alkyl, heteroalkyl, alkenyl, heteroalkenyl, alkynyl, heteroalkynyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aralkyl or heteroaralkyl radical, any of which may also be substituted with at least one halogen; R3 is selected from one of the following structures: ** see formulas ** m is an integer 1, 2 or 3; n is an integer 1, 2, 3, 4, 5 or 6; A-B together are -CHR4-CH-, -CR5 = C- or -CO-CH-; each X, independently of one another, is a bond, an oxygen atom, a sulfur atom, a group of formula CR6R7, CO, NR8, an optionally substituted cycloalkylene group, an optionally substituted heterocycloalkylene, an optionally substituted arylene, or an optionally substituted heteroarylene; each Y, independently of one another, is a bond, an oxygen atom, a sulfur atom, a group of formula CR6R7, CO, NR8, an optionally substituted cycloalkylene group, an optionally substituted heterocycloalkylene, an optionally substituted arylene, or an optionally substituted heteroarylene; R4 is a hydrogen atom, a halogen atom, or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl radical; R5 is a hydrogen atom, or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl radical; R6 radicals, independently of each other, are a hydrogen atom, or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl radical; R7 radicals, independently of each other, are a hydrogen atom, or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl radical; R8 radicals, independently of one another, are a hydrogen atom, or an alkyl, alkenyl, alkynyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, heterocycloalkyl, aralkyl or heteroaralkyl radical; R9 is a hydrogen or is an alkyl, heteroalkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aralkyl or heteroaralkyl radical, or R2 and R9 with the nitrogen atom may form a heteroaryl or heteroaralkyl; and R10 is a hydrogen or is an alkyl or heteroalkyl; wherein, whenever mentioned, alkyl refers to a saturated straight or branched chain hydrocarbon group having 1 to 20 carbon atoms; alkenyl and alkynyl refers to at least partially unsaturated, straight or branched chain hydrocarbon groups having from 2 to 20 carbon atoms; where in an alkyl, alkenyl or alkynyl, one or more hydrogen atoms are replaced by a halogen atom -COOH, -OH, -SH, -SO (0-2) R4, -NH2, -NO2, = O, = S, = NH; heteroalkyl refers to groups of formulas Ra-O-Ya-, Ra-S-Ya-, Ra-N (Rb) -Ya-, Ra-CO-Ya-, Ra-O-CO-Ya-, Ra-COOYa -, Ra-CO-N (Rb) -Ya-, Ra-N (Rb) -CO-Ya-, Ra-O-CO-N (Rb) -Ya-, Ra-N (Rb) -CO-O -Ya-, Ra-N (Rb) -CO-N (Rc) -Ya-, Ra- OCO-O-Ya-, Ra-N (Rb) -C (= NRd) -N (Rc) -Ya- , Ra-CS-Ya-, Ra-O-CS-Ya-, Ra-CS-O-Ya-, Ra-CS-N (Rb) -Ya-, Ra-N (Rb) - CSYa-, Ra- O-CS-N (Rb) -Ya-, Ra-N (Rb) -CS-O-Ya-, Ra-N (Rb) -CS-N (Rc) -Ya-, Ra-O-CS-O -Ya-, Ra-S-CO-Ya-, Ra-COSYa-, RaS-CO-N (Rb) -Ya-, Ra-N (Rb) -CO-S-Ya-, Ra-S-CO- O-Ya-, Ra-O-CO-S-Ya-, Ra-S-CO-S-Ya-, Ra-S-CS-Ya-, Ra- CS-S-Ya-, Ra-S-CS -N (Rb) -Ya-, Ra-N (Rb) -CS-S-Ya-, Ra-S-CS-O-Ya-, Ra-O-CS-S-Ya-, whereby Ra is a hydrogen atom, a C1-C6 alkyl group, a C2-C8 alkenyl or a C2-C6 alkynyl; Rb is a hydrogen atom, a C1-C6 alkyl group, a C2-C6 alkenyl or a C2-C6 alkynyl; Rc is a hydrogen atom, a C1-C6 alkyl group, a C2-C6 alkenyl or a C2-C6 alkynyl; Rd is a hydrogen atom, a C1-C6 alkyl group, a C2-C6 alkenyl or a C2-C6 alkynyl and is already a direct bond, a C1-C6 alkylene group, a C2-C6 alkenylene or a C2-C6 alkynylene , whereby each heteroalkyl group contains at least one carbon atom and one or more hydrogen atoms can be replaced by fluorine or chlorine atoms, where the heteroalkyl groups can also be nitrile, isonitrile, cyanate, thiocyanate, isocyanate, isothiocyanate groups or C1-C20 alkylnitrile; Cycloalkyl (also in cycloalkylene) refers to a saturated or partially unsaturated cyclic group, which has 1 or 2 or 3 rings forming a frame, containing 3 to 14 carbon atoms, or said group in which one or more atoms of hydrogen are replaced by fluorine, chlorine, bromine or iodine atoms or -COOH, -OH, = O, -SH, = S, -NH2, = NH, -NO2, alkyl or heteroalkyl groups are alkyl and heteroalkyl as defined above , or in the case of optionally substituted cycloalkylene as defined below; heterocycloalkyl (also in heterocycloalkylene) refers to a cycloalkyl group as defined above, in which 1, 2 or 3 carbon ring atoms are replaced by an oxygen, nitrogen, silicon, selenium, phosphorus or sulfur atom and having 1 or 2 rings with 3 to 10 ring atoms, or said group in which one or more hydrogen atoms are replaced by fluorine, chlorine, bromine or iodine atoms or -COOH, -OH, = O, -SH, = S, -NH2, = NH, -NO2, alkyl or heteroalkyl groups with alkyl and heteroalkyl as defined above, or in the case of optionally substituted cycloalkylene as defined below; "alkylcycloalkyl" refers to a group that, according to the above definitions, contains both cycloalkyl and alkyl, alkenyl or alkynyl groups as defined above, where in addition the cycloalkyl group has one or two rings with 3 to 10 carbon ring atoms, and one or two alkyl, alkenyl or alkynyl groups are present with 1 or 2 to 6 carbon atoms; "heteroalkylcycloalkyl" refers to alkylcycloalkyl groups as defined above, in which 1, 2 or 3 carbon ring atoms and / or carbon atoms are replaced by an oxygen, nitrogen, silicon, selenium, phosphorus or sulfur atom, where the heteroalkylcycloalkyl group possesses 1 or 2 rings with 3 to 10 ring atoms and one or two alkyl, alkenyl, alkynyl or heteroalkyl groups, each as defined above with 1 or 2 to 6 carbon atoms and whereby the cyclic groups are saturated or are mono-, di- or tri-unsaturated; Aryl (also in arylene) refers to an aromatic group, which has one or more rings with 6 to 14 carbon rings, or said group in which one or more hydrogen atoms are replaced by fluorine, chlorine, bromine or bromine atoms. iodine or -COOH, -OH, -SH, = NH, -NO2, alkyl or heteroalkyl groups, where alkyl and heteroalkyl are as defined above, or in the case of optionally substituted arylene as defined below; heteroaryl (also in heteroarylene) refers to an aromatic group containing one or more rings with 3 to 14 ring atoms, and 1, 2, 3 or 4 ring atoms of oxygen, nitrogen, phosphorus or sulfur, or said group in which one or more hydrogen atoms are replaced by fluorine, chlorine, bromine or iodine atoms or -COOH, -OH, -SH, = NH, -NO2, alkyl or heteroalkyl groups with alkyl and heteroalkyl as defined above, or in the case of optionally substituted heteroarylene as below; Aralkyl refers to groups that, according to the above definitions, contain any aryl and alkyl, alkenyl, alkynyl and / or cycloalkyl groups, in order to contain one or two aromatic rings with 6 to 10 carbon ring atoms and one or two alkyl, alkenyl and / or alkynyl groups as defined above with 1 or 2 to 6 carbon atoms and / or a cycloalkyl group as defined above with 5 or 6 carbon ring atoms; "heteroaralkyl" refers to an aralkyl group as defined above, which contains one or two aromatic rings with 5 or 6 to 10 carbon ring atoms and one or two alkyl, alkenyl and / or alkynyl groups as defined above with 1 or 2 at 6 carbon atoms and / or a cycloalkyl group as defined above with 5 or 6 carbon ring atoms, whereby 1, 2, 3 or 4 of these carbon atoms are replaced by oxygen, sulfur or nitrogen atoms and the cyclic groups are saturated or are mono-di- or tri-unsaturated; where the terms alkylcycloalkyl, heterocyclylcycloalkyl, aralkyl and heteroaralkyl additionally refer to groups in which one or more hydrogen atoms are replaced by fluorine, chlorine, bromine or iodine atoms or OH groups, = O, SH, = S, NH2, = NH or NO2, and aryl and heteroaryl in addition to the corresponding substituted fractions mentioned above refer to groups in which one or more hydrogen atoms are replaced by = O, = S or NH2 groups; and where "optionally substituted" refers to groups in which one or more hydrogen atoms are replaced, for example, by fluorine, chlorine, bromine or iodine atoms or -COOH, -OH, = O, -SH, = S, -NH2, = NH, -NO2, alkyl or heteroalkyl groups with alkyl and heteroalkyl as defined above, or also refers to groups that are substituted by unsubstituted groups C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C3-C10 cycloalkyl, C2-C9 heterocycloalkyl, C6-C10 aryl, C1-C9 heteroaryl, C7-C12 aralkyl or C2-C11 heteroaralkyl as otherwise defined above; or a pharmacologically acceptable salt, solvate, hydrat |
| priorityDate | 2005-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 472.