http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2328186-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D223-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D223-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-55 |
| filingDate | 2007-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_258ed0764c7a5a37b0f27c8d6707f2cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92e4a6694067f1ee9ca3299699eaa4b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39a0cd34c8e877db1898a00335ef0f2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a134dc125254d006b5deddf983baa385 |
| publicationDate | 2009-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2328186-T3 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF AN INTERMEDIATE OF ANTAGONIST OF THE CGRP DE CAPROLACTAMA. |
| abstract | Method of preparing (3R, 6S) -3-amino-6- (2,3-diflurophenyl) -1- (2,2,2-trifluoroethyl) azepan-2-one, or a salt thereof, said said comprising Process the steps of: (1) hydrogenate a salt of (3S) -6- (2,3-difluorophenyl) -2-oxo-1- (2,2,2-trifluoroethyl) -2,3,4,7- tetrahydro-1H-azepin-3-ammonium, in the presence of a cis-selective catalyst, to form a salt of (3S, 6S) -6- (2,3-difluorophenyl) -2-oxo-1- (2,2 , 2-trifluoroethyl) azepan-3-ammonium; (2) react the (3S, 6S) -6- (2,3-difluorophenyl) -2-oxo-1- (2,2,2-trifluoroethyl) azepan-3-ammonium salt with R 3N, in the that each R is independently C 1-4 alkyl, and a hydroxyl nitrobenzaldehyde; and (3) optionally reacting the product of step (2) with acid to form a salt thereof. |
| priorityDate | 2006-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 90.