| abstract |
1. Derivatives of 4-ethynyl isoxazole of the formula I ** see formula ** wherein, R1 / R2 / R3 are, independently of each other with respect to hydrogen, C1-C7 alkyl, halogen, C1-C7 alkoxy, or amino; R4 is C1-C7 alkyl; R5, is aryl or heteroaryl, optionally substituted, wherein the substituents are selected from the group consisting of C1-C7 alkyl, C1-C7 alkoxy, CF3, halogen, hydroxy, amino, - (CH2) n-CN, -C (O) O-C1-C7 alkyl, S (O) 2 NH2, -C (O) -NH- (CH2) n-cycloalkyl, -C (O) -NH-heterocycle, C (O) -NH -heteroaryl, optionally substituted aryl, wherein the substituents are selected from halogen; n is 0 or 1; as well as pharmaceutically acceptable acid addition salts thereof. |