| abstract |
Compound having the formula I: ** see formula ** in which: W is A-B-D; A is aryl (CH2) n, heteroaryl (CH2) n, alkyl having one to 14 carbon atoms, alkenyl having two to 14 carbon atoms or cycloalkyl having 3 to 10 carbon atoms, being optionally substituted said group A by one or more groups J; B is a bond or CO, SO, SO2, OCO, NR5CO, NR5SO2 or NR5SO; D is an amino acid residue or bond, said amino acid residue or residues being defined independently by the formula -NH - ** CH (R6) -CO-, in which ** denotes the alpha carbon atom of a residue of alpha-amino acid that possesses, when R6 is different from hydrogen, the D configuration, the L configuration or a mixture D and L; n is an integer from 0 to 6; R1 is alkyl having one to 14 carbon atoms, said alkyl being optionally substituted by J ", where J" is C1-6 alkoxy; R2 is alkyl having one to 14 carbon atoms, said alkyl being optionally substituted by J ", where J" is arylalkyl or aryl; R3 is H; R4, R5 and R6 are independently hydrogen, alkyl having one to 14 carbon atoms, or cycloalkyl having 3 to 10 carbon atoms, said alkyl and cycloalkyl groups being optionally substituted by one or more J groups; and J is halogen, C1-6 alkyl, aryl, heteroaryl, haloaryl, amino optionally substituted by one to three aryl or C1-6 alkyl groups, guanidino, alkoxycarbonyl, amido, C1-6 alkyl amido, sulfonamido, C1-6 alkyl sulfonamido , C1-6 alkyl sulfonyl, C1-6 alkyl sulfoxy, C1-6 alkyl thio, C1-6 alkoxy, aryloxy, arylalkyl, hydroxy, carboxy, cyano or nitro; and * denotes the carbon atom of an -amino acid residue that it possesses, when R2 is different from hydrogen, the D configuration, the L configuration or a mixture of the D and L configurations, or their pharmaceutically acceptable salts, in which the The term "alkyl" includes straight chain, branched and cyclic hydrocarbon groups. |