| abstract |
A compound represented by the structural formula ** see formula ** or a pharmaceutically salt thereof, where ** see formula ** represents (a) a double bond or (b) ** see formula ** m is 0 or 1; n is 0 or 1, where the sum of n and m is 1 or 2; p is 2 or 3; X is selected within the group consisting of: ** see formula ** R 1 is ** see formula ** R 2 is ** see formula ** R3 is - (CR 5 R 6) -NR 7 R 8; R 8 and R 8 are hydrogen; R 7 is hydrogen or alkyl; R 8 is hydrogen or alkyl; ES 2 327 763 T3 or R 7 and R 8, taken together and with the nitrogen to which they are attached, form a heterocyclyl ring, wherein said heterocyclyl ring may be optionally substituted with hydroxy; R 10 is a moiety selected from the group consisting of hydrogen and hydroxyl; R 11 is hydrogen or alkyl; R 12 is 1 or 2 moieties and each R 12 is independently selected from the group consisting of hydrogen, alkyl, alkoxyalkyl or hydroxyalkyl; Ar is aryl substituted with (R 13) 2 or heteroaryl substituted with (R 13) 2, and each R 13 is independently selected from the group consisting of halo and -CF3. |