abstract |
A compound of the formula (I) ** see formula ** In which X is CH or N, Y is O, S or NR4, in which R4 is H or C1-3 alkyl; Z is H or halogen; R1 is C1-6 alkyl substituted with 1 to 2 groups independently selected from trifluoromethyl, C2-5 alkanoyl, C3-7 cycloalkyl, phenyl, phenoxy, a heterocyclic group and a heteroaryl group; C3-7 cycloalkyl optionally substituted with C1-3alkyl; or a heterocyclic group; wherein - the heteroaryl group is an aromatic ring system of 4 to 7 elements having either 1 to 4 atoms of N or 0 to 2 atoms of N and 1 atom of O or 1 atom of S in the ring; - the heterocyclic group is a saturated ring system of 4 to 7 elements that has either 1 to 4 N atoms or 0 to 2 N atoms and 1 O atom or 1 S atom in the ring; - the phenyl, phenoxy, and heteroaryl groups mentioned in the definitions of R1 are optionally substituted with at least one substituent selected from halogen, C1-4 alkyl, C1-4 haloalkyl, hydroxy, C1-4 alkoxy, C1-4 haloalkoxy, cyano , C1-4 hydroxyalkyl, (C1-4 alkoxy) -C1-4 alkyl, C1-4 alkyl sulfonyl, C2-5 alkanoyl, C2-4 alkenyl, C2-4 alkynyl, C1-4 alkylthio, nitro, amino, mono- or di- (C1-4 alkyl) amino, aminosulfonyl, C1-4 alkoxycarbonyl, C1-4 alkyl sulfonylamino, C3-7 cycloalkyl and a mono- or di- (C1-6 alkyl) aminocarbonyl; and R2 and R3 are independently H or C1-3 alkyl; or R2 and R3 together form a C3-6 alkylene chain; or a pharmaceutically acceptable ester or salt thereof. |