| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42b66fd6ac8d432f925152eef843ebe7 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2799-026
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96472 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6478
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
| filingDate |
2000-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c464e64c429b1e7b1909e2894436aced
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4a0b681c6e18e688e0c41ae78a57a09 |
| publicationDate |
2009-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
ES-2327312-T3 |
| titleOfInvention |
SECRETASE OF ALZHEIMER'S DISEASE, SUBSTRATES APP FOR THE SAME, AND USES FOR THE SAME. |
| abstract |
A method for evaluating the activity of hu-Asp1 alpha-secretase, which comprises the steps of: (a) contacting a hu-Asp1 polypeptide, which comprises an amino acid sequence identical in at least 95% to a fragment, which includes the DTG and DSG tripeptides of the active site of aspartyl proteases, of the amino acid sequence of SEQ ID NO: 2, in which the polypeptide and the fragment retain an alpha-secretase activity, with the precursor protein substrate of the amyloid (APP) that contains an alpha-secretase cleavage site, and (b) measure the cleavage of the APP substrate at the alpha-secretase cleavage site of hu-Asp1. |
| priorityDate |
1999-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |