http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2327253-T3
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f2d3599fb8f8f479dba95ca9bb504884 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-505 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 |
filingDate | 2005-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2009-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_24dc46d92084f5ffa5d19f11d75324b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f448178ae3b12c9e2cf7c7d3f4250e9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a2ffa1e48c92b192d5facecb683d68d5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20fd9e73623bad885e2dd0b458737dff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_245f503e43ef8f5a77accfc0ada70b52 |
publicationDate | 2009-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2327253-T3 |
titleOfInvention | DERIVATIVES OF PROPENIL PIPERAZINA SUBSTITUTED AS NEW INHIBITORS OF HISTONA DEACETILASA. |
abstract | A compound of formula (I), ** see formula ** N-oxide forms, pharmaceutically acceptable addition salts and its stereochemically isomeric form, wherein each X is independently N or CH; R 1 is phenyl, naphthalenyl or heterocyclyl; wherein each of said phenyl or naphthalenyl is optionally substituted with one or two substituents each independently selected from halo, C 1-6 alkyl, C 1-6 alkyl, oxyC 1-6 polyhaloalkyl, aryl, hydroxy, cyano , amino, C 1-6 alkylcarbonylamino, C 1-6 alkyl sulfonylamino, hydroxycarbonyl, C 1-6 alkyl oxycarbonyl, C 1-6 hydroxyalkyl, C 1-6 alkyl oxymethyl, aminomethyl, C 1-6 alkyl aminomethyl, C1-6 alkylcarbonylaminomethyl, C1-6 alkyl sulfonylaminomethyl, aminosulfonyl, C1-6 alkyl aminosulfonyl or heterocyclyl; R 2 is hydrogen, -CH 2-R 5, trifluoromethyl, -C (= O) -R 6, or -CH 2-NR 7 R 8; wherein each R 5 is independently selected from hydrogen, hydroxy, C1-6-oxy alkyl, C1-6-oxy-C1-6oxy alkyl, C1-6 alkylcarbonyloxy, piperazinyl, N-methylpiperazinyl, morpholinyl, thiomorpholinyl, imidazolyl or triazolyl; each R 6 is independently selected from hydroxy, C 1-6 alkyl, amino or mono- or di- (C 1-6 alkyl) amino, C 1-6 cycloalkyl, C 1-6 hydroxyalkyl, piperazinyl , mono- or di- (C 1-6 alkyl) aminoC 1-6 alkyl-amino Nmethylpiperazinyl, morpholinyl or thiomorpholinyl; each R 7 and R 8 are independently selected from hydrogen, C 1-6 alkyl, C 1-6 alkylcarbonyl, C 1-6 alkyl sulfonyl, or mono- or di- (C 1-4 alkyl) -aminosulfonyl; R 3 is hydrogen, hydroxymethyl, aminomethyl or mono- or di- (C1-6 alkyl) aminomethyl; R 4 is hydrogen or C 1-6 alkyl; aryl in the foregoing is phenyl or naphthalenyl; wherein each of said phenyl or naphthalenyl is optionally substituted with one or two substituents each independently selected from halo, C 1-6 alkyl, C 1-6 alkyl, trifluoromethyl, cyano or hydroxycarbonyl; and heterocyclyl is furanyl, thienyl, pyrrolyl, pyrrolinyl, pyrrolidinyl, dioxolyl, oxazolyl, thiazolyl, imidazolyl, imidazolinyl, imidazolidinyl, pyrazolyl, pyrazolinyl, pyrazolidinyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, thiadiazolyl, pyranyl, pyridinyl, piperidinyl, dioxanyl, morpholinyl , dithianyl, thiomorpholinyl, pyridazinyl, pyrimidinyl, pyrazinyl, piperazinyl, triazinyl, trithianyl, indolizinyl, indolyl, indolinyl, benzofuranyl, benzothiophenyl, indazolyl, benzimidazolyl, benzthiazolyl, purinyl, quinolizinyl, quinolinyl, cinnolinyl, ftlazinilo, quinazolinyl, naphthyridinyl or quinaxolinilo; wherein each of said heterocycles is optionally substituted with one or two substituents each independently selected from halo, C 1-6 alkyl, C 1-6 alkyl, oxy, cyano, amino, or mono- or di- (C alkyl) 1-4) -amino. |
priorityDate | 2004-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1380.