http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2326956-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D473-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D473-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-522 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-00 |
| filingDate | 2001-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d77bf4c2727a530ee196b86b25d5518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5cd896d02f0a225e704543422bea06d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8e8470b25e958a5d856a0db31b489380 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_afabe4132e4fc910f8841120eca5000d |
| publicationDate | 2009-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2326956-T3 |
| titleOfInvention | XANTINA V PHOSPHODIESTERASE INHIBITORS. |
| abstract | A compound that includes an enantiomer, stereoisomer, rotamer and / or tautomer thereof, or a pharmaceutical composition thereof, said compound being represented by the formula (I): ** see formula ** in which: (a) R 1 and R 2 are independently of each other, each of them a C 1 -C 15 alkyl group, straight or branched chain, with or without one or more substituents, a C 2 -C 15 alkenyl group, straight or branched chain, with or without one or more substituents, a C2-C15 alkynyl group, straight or branched chain, with or without one or more substituents, a C3-C15 cycloalkyl group, with or without one or more substituents, an arylalkyl group, with or without one or more substituents, an aryl group, with or without one or more substituents, a heteroaryl group, with or without one or more substituents, -OR 5, -COOR 5, -C (O) R 5 O (C (O) N (R 5) 2, where R 5 is a hydrogen atom or a hydrocarbon radical, with or without one or more substituents, or one of R 1 and R 2 is a hydr atom geno, and the other R R 1 to 2 is defined as stated above; (b) R 3 is an aryl group, with or without one or more substituents, a heteroaryl group, with or without one or more substituents, a heterocyclic group having 1 to 3 heteroatoms fused with an aryl ring of 5 or 6 links, with or without one or more substituents, as long as R 3 is not an aryl group substituted in its position towards a -Y-aryl group, in which Y is a simple carbon-carbon bond, -CO-, - O-, -S-, -N (R 21) -, CON (R 22) -, -N (R 22) CO-, -OCH 2-, -CH2O, -SCH2-, -CH2S-, -NHC ( R 23) (R 24) -, -NR 23 SO2-, -SO2NR 23, -C (R 23) (R 24) NH-, -CO = CH-, CF = CF-, -CH = CF-, - CF = CH-, CH2CH2-, -CF2CF2, ** see formula ** in which: R 21 is a hydrogen atom or a group -CO (C1-C4 alkyl)), C1-C6 alkyl, allyl, cycloalkyl of C3-C6, phenyl or benzyl; R 22 is a hydrogen atom or a C 1 -C 6 alkyl group; R 23 is a hydrogen atom or a C1-C5 alkyl group, aryl or a -CH2-aryl group; R 24 is a hydrogen atom or a C1-C4 alkyl group; R 25 is a hydrogen atom or a C1-C8 alkyl group, C1-C8 perfluoroalkyl, C3-C6 cycloalkyl, phenyl, or benzyl; R 26 is a hydrogen atom or a C 1- C 6 alkyl, C 3- C 6 cycloalkyl or a benzyl group; R 27 is -NR 23 R 24, -OR 24, -NHCONH 2, -NHCSNH 2, ** see formula ** and R 28 and R 29 are independently of each other, each a C 1- alkyl group C 4, or taken together, a group - (CH 2) q, where q 2 or 3. (c) R 4 is a C3-C5 cycloalkyl group, with or without substituents, a C3-C15 cycloalkenyl group, with or without one or more substituents, or a heterocycloalkyl group of 3 to 15 links, with or without one or more substituents; the substituent or more substituents being chemically compatible for all groups and, independently of each other, each one: an alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, arylalkyl, alkylaryl, aryl, heteroaryl and heterocycloalkyl, hydroxyalkyl, arylalkyl group, aminoalkyl, haloalkyl, thioalkyl, alkylthioalkyl, carboxyalkyl, imidazolyl alkyl, indolyl alkyl, mono-, di- or trihaloalkyl, mono-, di- and trihaloalkoxy, amino, alkylamino, dialkylamino, alkoxy, hydroxy, halo, nitro, oximino, -CO -COR 50, -SO0-2R 50, -SO2NR 50 R 51, NR 52 SO 2R 50, = C (R 50 R 51), = N-OR 50, = N-CN, = C (halo) 2, = S, = O, -CON (R 50 R 51), -OCOR 50, -OCON (R 50 R 51), -N (R 52) CO (R 50), N (R 52) COOR 50 or -N ( R 52) CON (R 50 R 51), where: R 50, R 51 and R 52 are each independently selected from the following: a hydrogen atom and an optionally substituted linear or branched chain group, C1 alkyl -C6, C3-C6 cycloalkyl, C4-C6 heterocycloalkyl, heteroaryl or aryl; or R 50 and R 51 can be joined to form a carbocyclic or heterocyclic ring system; or R 50, R 51 and R 52 are independently of each other: ** see formula ** where: R 40 and R 41 are independently of each other, each of them a hydrogen atom, a group of linear or branched chain, optionally substituted alkyl, cycloalkyl, heterocycloalkyl, halo, aryl, imidazolyl alkyl, indolylalkyl, heteroaryl, arylalkyl, arylalkoxy, heteroarylalkyl, heteroarylalkyl, aminoalkyl, haloalkyl, mono-, di- or trihaloalkoxy, , nitro, cyano, alkoxy, hydroxy, amino, phosphino, phosphate, alkylamino, dialkylamino, formyl, alkylthio, trialkylsilyl, alkylsulfonyl, arylsulfonyl, alkylsulfinyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, hydroxyalkyl, morpholino, thioalkyl, alkylthioalkyl, carboxyalkyl, oximino, - COOR 50, -COR 50, -SO 0-2R 50, -SO 2NR 50 R 51, NR 52 SO 2R 50, -CON (R 50 R 51), -OCON (R 50 R 51), -N (R 52 ) CO (R 50) and -N (R 52) COOR 50, -N (R 52) CON (R 50 R 51) or -OCONR 50 if endo R 50 and R 51 as defined above; R 42 is a hydrogen atom or a linear or branched chain group, optionally substituted, alkyl, alkenyl, arylalkyl or acyl; and R 43 is a hydrogen atom or a linear or branched chain group, optionally substituted alkyl or aryl; the optional substituents being defined as defined above for one or more substituents. |
| priorityDate | 2000-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 142.