http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2326750-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D231-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 |
| filingDate | 2005-10-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4b9ca09b9924e90fe0681f0c9b7e1d29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96810d831540df667d63006d9b395665 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_56e9155e375a5e7b5600375e4645fe27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f9ca6de64eeb02c108fb37bc16edb704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4d9b81b5f0e7e52ac7fc90b6b42eb1e7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fa094b9eb76d42b9cbc33eb8c84afeb |
| publicationDate | 2009-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2326750-T3 |
| titleOfInvention | 5-CARBOXIAMIDO PIRAZOLES AND (1,2,4) TRIAZOLS AS ANTIVIRAL AGENTS. |
| abstract | A compound of Formula (I): ** (See formula) ** or a pharmaceutically acceptable salt, solvate or ester thereof, in which: X is C (R8) or N; R8 is H; halo, CF3, C1-C6 alkyl, C1-C6 haloalkyl, -OH, -SH, C1-C6 alkoxy, C1-C6 alkylthio, -NH2, -NH (C1-C6 alkyl) or -N (C1-C6 alkyl) 2; Y is C (O) or S (O) 2; R1 is -CO2R9, -C (O) R9, -C (O) NR9R10, -NR9C (O) R10, -NR9SO2R10, -NR9SO2NR9R10, -C (O) N (R9) OR10, -NR9C (O) NR9R10, -NR9C (O) OR10, -C (O) NR9SO2R10, -C (O) NR9NR9R10, -CN, -NR9C (O) CF3, -NR9SO2CF3, -CH = NOR21, -C (O) NR9CN, -C (O ) NR9 (CR19R20) 1-12R11, -C (O) N ((R19R20) 1-12R11) 2, -NR9C (O) NR9 (CR19R20) 1-12CO2R9, H, -OH, C1-C6 hydroxyalkyl, C1 alkyl -C6, unsubstituted tetrazolyl, tetrazolyl substituted with one or more moieties that may be the same or different and that are independently selected from the group consisting of alkyl, cycloalkyl, halo and aryl, unsubstituted thienyl, substituted thienyl with one or more moieties which they can be the same or different and are independently selected from the group consisting of alkyl, cycloalkyl, halo and aryl; R2 is cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, alkyl or cycloalkyl, where each R2 member is optionally substituted with 1-4 R12 moieties; R3 is H or C1-C6 alkyl; R4 is H, C1-C6 alkyl or C1-C6 alkoxy; R5 is H, C1-C6 alkyl or C1-C6 alkoxy; R6 is cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, alkyl or cycloalkylalkyl, where each R2 member is optionally substituted with 1-4 R12 moieties; R7 is H or C1-C6 alkyl; or R6 and R7, when bound to the same nitrogen, are optionally taken together with the attached nitrogen to form a five to seven member ring having an additional 0-1 heteroatom selected from N, O or S (in addition to said bound nitrogen) , wherein said five to seven member ring is optionally substituted with 1-3 R18 moieties; each R9 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl, where each member, except H, is optionally substituted with 1-4 residues R12; each R10 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl, where each member, except H, is optionally substituted with 1-4 residues R12; or R9 and R10 when bound to the same nitrogen are optionally taken together with the attached nitrogen to form a five to sixteen monocyclic, bicyclic or tricyclic ring having 0-2 additional heteroatoms (in addition to said bound nitrogen) selected from N, O or S, wherein said monocyclic, bicyclic or tricyclic ring is optionally substituted with 1-3 R18 moieties; R11 is -NR13SO2R14, -CO2R13, -OR13, -C (O) NR13R14, -NR13R14 or -C (O) NR13 (CR19R20) 1-12CO2R21; Each R12 is independently halo, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, -CN, -CF3, -OR13, -SR13, -C (O) R13, -C (S) R13, -C (O) OR13, -C (S) OR13, -OC (O) R13, -OC (S) R13, -C (O) NR13R14, -C (S) NR13R14, -C (O) NR13OR14, - C (S) NR13OR14, -C (O) NR13NR13R14, -C (S) NR13NR13R14, -C (S) NR13OR14, -C (O) SR13, -NR13R14, -NR13C (O) R14, -NR13C (S) R14 , -NR13C (O) OR14, -NR13C (S) OR14, -OC (O) NR13R14, -OC (S) NR13R14, -NR13C (O) NR13R14, -NR13C (S) NR13R14, -NR13C (O) NR13OR14, -NR13 C (S) NR13OR14, - (CR19R20) 1-6OR13, - (CR19R20) 1-6SR13, -SO2R13, -S (O) 1-2NR13R14, -N (R13) SO2R14, -N (R13) SO2 NR13R14 , -S (O) 1-2NR13OR14, -OCF3, -SCF3, -C (= NR13) NR14, -C (O) NR13 (CH2) 1-10NR13R14, -C (O) NR13 (CH2) 1-10 OR14 , -C (S) NR13 (CH2) 1-10NR13R14, -C (S) NR13 (CH2) 1-10OR14, haloalkyl, = O, = S, NO2, -C (O) C (O) R13, -C (O) CH2C (O) R13, methyldioxy or ethylenedioxy, wherein each of said alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aral chyl, heteroaryl or heteroaralkyl is optionally substituted with 1-4 R15 moieties; each R13 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl, where each member of R13, except H, is optionally substituted with 1-4 residues R15; each R14 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl, where each member of R14, except H, is optionally substituted with 1-4 residues R15; or R13 and R14, when bound to the same nitrogen, are optionally taken together with the attached nitrogen to form a five to seven member ring having an additional 0-1 heteroatom selected from N, O or S (in addition to said bound nitrogen) , wherein said five to seven member ring is optionally substituted with 1-3 R18 moieties; Each R15 is independently halo, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, -CN, -CF3, -OR16, -SR16, -C (O) R16, -C (S) R16, -C (O) OR16, -C (S) OR16, -OC (O) R16, -OC (S) R16, -C (O) NR16R17, -C (S) NR16R17, -C (O) NR16OR17, - C (S) NR16OR17, -C (O) NR16NR16R17, -C (S) NR16NR16R17, -C (S) NR16OR17, -C (O) SR16, -NR16R17, -NR16C (O) R17, -NR16C (S) R17 , -NR16C (O) OR17, -NR16C (S) OR17, -OC (O) NR16R17, -OC (S) NR16R17, -NR16C (O) NR16R17, -NR16C (S) NR16R17, -NR16C (O) NR16OR17, -NR16 C (S) NR16OR17, - (CR19R20) 1-6OR16, - (CR19R20) 1-6SR16, -SO2R16, -S (O) 1-2NR16R17, -N (R16) SO2R17, -S (O) 1- 2NR16 OR17, -OCF3, -SCF3, -C (= NR16) NR17, -C (O) NR16 (CH2) 1-10NR16R17, -C (O) NR16 (CH2) 1-10OR17, -C (S) NR16 ( CH2) 1-10NR16R17, -C (S) NR16 (CH2) 1-10OR17, haloalkyl, = O, = S, NO2, -C (O) C (O) R16, -C (O) CH2C (O) R16 , methyldioxy or ethylenedioxy, wherein each of said alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl is optionally substituted with 1-3 R18 moieties; each R16 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl, where each member of R16 is optionally substituted with 1-3 R18; each R17 is independently H, alkyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, aralkyl, heteroaryl or heteroaralkyl, where each member of R16 is optionally substituted with 1-3 R18; or R16 and R17, when bound to the same nitrogen, are optionally taken together with the attached nitrogen to form a five to seven membered ring having an additional 0-1 heteroatom selected from N, O or S (in addition to said bound nitrogen) , wherein said five to seven member ring is optionally substituted with 1-3 R18 moieties; each R18 is halo, = O, = S, NO2, alkyl, -OR21, -CN, -NR21R22, -C (O) R21, -C (O) OR21, -C (O) NR21R22, -CF3, -N (R21) C (O) R22, - (CH2) 1-4-O- (CH2) 1-4-phenyl, phenyl or benzyl, wherein said phenyl or benzyl is optionally substituted with 1-3 R23; each R19 is independently H, C1-C6 alkyl or C1-C6 alkoxy; each R20 is independently H, C1-C6 alkyl or C1-C6 alkoxy; each R21 is independently H or alkyl; each R22 is independently H or alkyl; and each R23 is independently halo, -NO2, alkyl, -OR21, -CN, -NR21R22, -C (O) R21, -C (O) OR21, -C (O) NR21R22, -CF3 or -N (R21) C (O) R22. |
| priorityDate | 2004-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 294.