| abstract |
A rapidly intraorally disintegrable tablet containing a pharmacologically active ingredient with a water solubility of at least 0.5 mg / ml, which can be produced by granulating to the extent of dust a particle comprising (1) a pharmacologically active ingredient with a water solubility of at least 0.5 mg / ml, (2) D-mannitol in the form of crystals with an average diameter of the main particle of at least 30 mim and a specific surface area of 0.4 m 2 / g or less , and (3) crospovidone, followed by compression molding, further comprising a lubricant included only on the surface of the tablet. |