http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2324951-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1542e8802a0e6a7a8a7c6bd5627eb857 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-605 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-57563 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-605 |
| filingDate | 2005-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d861a4f5d9843086acf9b41c9b4c142 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eed58315b9ce78206865c95a8a7642c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_62034f5ef864698fe6589ee3e7cc0b75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f6d370c1a524608e5b5e391c958d1953 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9945ec9b3a26e4ef43b9ce9cd0e5cb26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5db697b27c16bc41ebba24d8cf6b357 |
| publicationDate | 2009-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2324951-T3 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF CARBOXI-TERMINAL AMBED PEPTIDES. |
| abstract | Process for the production of amidated peptides at the C-terminal of general formula II (AS) n-Xm-NH2 (formula II) in which AS means one or more genetically encodable amino acids; n is from 5 to 2000, preferably from 10 to 1000, in particular from 15 to 500, very especially preferably from 20 to 400; and (AS) n and / or (AS) n-Xm preferably means a biologically active peptide or protein, X means one or more basic amino acids or one of its derivatives, preferably lysine, histidine and / or arginine, in particular lysine; m is from 1 to 15, preferably from 3 to 10, in particular from 6 to 8; ynym means whole numbers and in which a) host cells are grown in a suitable nutrient medium, b) a compound of general formula I is expressed: (AS) n-XmYp (formula I), in which Y means one or more neutral amino acids, preferably glycine, p is 1 to 10, preferably 1 to 5, in particular 1; a) optionally the compound of the formula I is released from a suitable precursor peptide by enzymatic or chemical cleavage; b) the expression products of step b) or the intermediate products of step c), possibly after a purification step, are reacted with an alpha-amidant enzyme (PAM); and c) the peptide amidated at the C-terminal of the general formula II is suitably purified, preferably by a preparative chromatographic method. |
| priorityDate | 2004-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 240.