http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2324923-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_96259dd7b2c9d8fb77a90c71df96736c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2007-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_67c216fefe6d18c0b0a046c91bb84c0f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01206a6140b17a0010ecac1ba4f2b012 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2670238672bc59940214641a22e8b926 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d76a97b0233315fd6119273913b01968 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8c56cf0f211db70168ec1b98d4accf8f |
| publicationDate | 2009-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2324923-T3 |
| titleOfInvention | PROCEDURE FOR THE PREPARATION OF MOXIFLOXACINO AND MOXIFLOXACINO CHLORHYDRATE. |
| abstract | Process for the preparation of moxifloxacin, characterized in that the reaction of the compound of formula (II) ** see formula ** with a silylating agent of formula ZSiR3 is carried out in a "one pot" reaction, wherein Z is Me3SiNH- or Cl-, and R is interchangeably a C 1-4 alkyl chain or phenyl, within an aprotic polar solvent, to obtain the intermediate compound of formula (VI), ** see formula * * which, without being isolated, is then reacted with a boron trifluoride compound to obtain the intermediate compound of formula (VII) ** see formula **, which is not isolated and subsequently reacted with (S, S) -2 , 8-diaza-bicyclo [4.3.0] nonane (III), after adjusting the pH to a value between 8 and 9, obtaining intermediate compound (VIII) ** see formula ** that without being isolated is reacted with a C 1-4 chain alcohol to yield moxifloxacin and, optionally, form the moxifloxacin hydrochloride salt, with a content of less than 0.1% of the by-product resulting from the demethylation of the methoxy group at position 8 of the ring. |
| priorityDate | 2006-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 58.