http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2324231-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate | 2005-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4ad1b2940213e774425c7985b808573 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f420c5a22a29e9093f14e38f2f83a76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_83413618aa6a15ca8b99b862f10a8ecf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1de1ede11d052d5f921eec15214131d0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f86ce639ce040201c8591fd70ee9c73 |
| publicationDate | 2009-08-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2324231-T3 |
| titleOfInvention | DERIVATIVES OF TIENO-PIRIDINA AS ALLOSTERIC INTENSIFIERS OF GABA-B. |
| abstract | Compounds of formula I ** see formula ** wherein: R 1 is hydrogen, alkyl of 1 to 7 carbon atoms or cycloalkyl of 3 to 8 carbon atoms; R2 is alkyl of 1 to 7 carbon atoms, CF3, cycloalkyl of 3 to 8 carbon atoms, optionally substituted aryl or optionally substituted heteroaryl having 5 to 9 ring atoms, wherein the substituents are selected from the group consisting of halo, alkoxy of 1 to 7 carbon atoms, alkylsulfonyl of 1 to 7 carbon atoms and -C (O) O-alkyl of 1 to 7 carbon atoms; R3 is -NRaRb; heterocycloalkyl optionally substituted with 3 to 8 ring atoms, optionally substituted aryl or heteroaryl optionally substituted with 5 to 9 ring atoms, wherein the substituents are selected from the group consisting of halo, alkoxy of 1 to 7 carbon atoms, alkylsulfonyl of 1 to 7 carbon atoms and -C (O) O-alkyl of 1 to 7 carbon atoms; R4 is hydrogen or alkyl of 1 to 7 carbon atoms; and R5 is hydrogen, halo, alkyl of 1 to 7 carbon atoms, optionally substituted aryl or heteroaryl optionally substituted with 5 to 9 ring atoms, wherein the substituents are selected from the group consisting of halo, alkyl of 1 to 7 carbon atoms, alkoxy of 1 to 7 carbon atoms and -C (O) O-alkyl of 1 to 7 carbon atoms; or R5 together with R4 forms a ring that is selected from the group consisting of cycloalkyl of 5 to 7 carbon atoms, phenyl, pyridinyl and pyrimidinyl, which are optionally substituted by one or more of halo, cyano, alkylsulfonyl of 1 to 7 carbon atoms, alkyl of 1 to 7 carbon atoms, haloalkyl of 1 to 7 carbon atoms, alkoxy of 1 to 7 carbon atoms, haloalkoxy of 1 to 7 carbon atoms or -C (O) O-alkyl of 1 at 7 carbon atoms; or heterocycloalkyl with 5 to 7 ring atoms, optionally substituted by one or more cyano, alkyl of 1 to 7 carbon atoms, alkoxy of 1 to 7 carbon atoms or C (O) O-alkyl of 1 to 7 atoms carbon; Ra and Rb are each independently alkyl of 1 to 7 carbon atoms, or Ra and Rb together with the nitrogen atom to which they are attached form an unsubstituted piperidine; or a pharmaceutically acceptable salt thereof. |
| priorityDate | 2004-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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