http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2323870-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34bd4e87ecbca17f16d460ca394e60f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C209-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C215-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C217-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C211-27 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C211-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C217-62 |
| filingDate | 2004-06-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f96c00cdcd3fc4a322c8312fb5d4b1a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f24eeca785743cf6014e323b25448c3d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3c3ee7315dc01d34df36dbab6d9c4607 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bfca67111ea685e6b2d8ea7fe1156bd9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5629a8b5fcd1628ce13227625c7cf18b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cae9ecac97ad9f3e11fbb6ac7adcc135 |
| publicationDate | 2009-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2323870-T3 |
| titleOfInvention | PROCEDURE FOR THE PRODUCTION OF SUBSTITUTED 3-ARIL-BUTIL-AMINA COMPOUNDS. |
| abstract | Process for the production of a substituted 3-aryl-butyl-amine compound of general formula I, ** see formula ** R 1 is selected from H, branched or unbranched (C1-3) alkyl, saturated or unsaturated, substituted by single or multiple or unsubstituted form; R 2 and R 3 are selected, in each case independently from each other, from H or (C 1-4) branched or unbranched, saturated or unsaturated alkyl, substituted simply or multiple or unsubstituted; or R 2 and R 3 together form a saturated (C 4-7) cycloalkyl group, substituted simply or multiplely or unsubstituted; R 4 is selected from H, branched or unbranched (C 1-3) alkyl, saturated or unsaturated, substituted simply or multiple or unsubstituted; R 7 and R 8 are selected, in each case independently from each other, from H or C 1-3 alkyl branched or unbranched, saturated or unsaturated, substituted simply or multiple or unsubstituted; R 9 to R 13 are selected, in each case independently from each other, from H, F, Cl, Br, I, CH 2F, CHF 2, CF 3, OH, SH, OR 14, OCF3, SR 14, NR 17 R 18, SOCH3, SOCF3; SO2CH3, SO2CF3, CN, COOR 14, NO2, CONR 17 R 18; C1-6 alkyl branched or unbranched, saturated or unsaturated, substituted in a single or multiple or unsubstituted form; single or multiple or unsubstituted substituted phenyl; or R 14 being selected from (C 1-6) alkyl; pyridyl, thienyl, thiazolyl, phenyl, benzyl or phenethyl, in each case substituted simply or multiple or unsubstituted; PO (O-C1-4 alkyl) 2, CO (O-C1-5 alkyl), CONH- C6H4- (C1-3 alkyl), CO (C1-5 alkyl), CO- CHR 17 -NHR 18, CO-C6H4-R 15, where R 15 is ortho-OCO-alkyl (C1-3) or meta- or para-CH2N (R 16) 2, with R 16 alkyl (C1-4) or 4 -morpholino, the alkyl groups of the groups R 14, R 15 and R 16 being branched or unbranched, saturated or unsaturated, substituted simply or multiple or unsubstituted; R 17 and R 18 being selected, in each case independently from each other, from H; C1-6 alkyl branched or unbranched, saturated or unsaturated, substituted in a single or multiple or unsubstituted form; phenyl, benzyl or phenethyl, in each case substituted simply or multiple or unsubstituted; R 9 and R 10 or R 10 and R 11 together form an OCH2O, OCH2CH2O, OCH = CH, CH = CHO, CH = C (CH3) O, OC (CH 3) = CH, (CH 2) 4 or OCH ring = CHO; in each case in the form of one of its pure stereoisomers, in particular of enantiomers or diastereoisomers, of its racemates or in the form of stereoisomers, in particular of enantiomers or diastereoisomers, in any proportion of mixture, or in each case in the form of a physiologically compatible salt, or in each case in the form of a solvate; characterized in that in a first step a) a 1-amino-3-aryl-3-butanol compound of general formula II is used ** see formula ** where R 1, R 2, R 3, R 4, R 7, R 8, R 9, R 10, R 11, R 12 and R 13 have the meaning indicated above, in each case optionally in the form of one of their pure stereoisomers, in particular of enantiomers or diastereoisomers, of their racemates or in the form of a mixture of stereoisomers, in particular of enantiomers or diastereoisomers, in any proportion of mixture, or in each case in the form of a physiologically compatible salt, or in each case in the form of a solvate, and is subjected to elimination under the action of an acid for obtain a substituted 3-aryl-3-butenyl-amine compound of general formula III, ** see formula ** where R 1, R 2, R 3, R 4, R 7, R 8, R 9, R 10, R 11, R 12 and R 13 have the meaning indicated above, in each case optionally in the form of one of their pure stereoisomers, in particular of enantiomers or diastereoisomers, of their racemates or in the form of a mixture of stereoisomers, in particular of enantiomers or diastereoisomers, in any proportion of mixture, or in each case in the form of a physiologically compatible salt, or in each case in the form of a solvate, and in a second step b) the substituted 3-aryl-3-butenyl-amine compound of general formula III thus obtained is then hydrogenated with the participation of a metal catalyst and hydrogen to obtain a substituted 3-aryl-butylamine compound of general formula I. |
| priorityDate | 2003-06-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 163.