http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2323555-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1542e8802a0e6a7a8a7c6bd5627eb857 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-51 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C69-74 |
| filingDate | 2006-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_03232714032c55b92b0023a8178c59df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aa9e2c0b0713b6ccd9bfe2a48c786fdf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33016a37977ce292fd4492e8262fa7b1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eed58315b9ce78206865c95a8a7642c6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f350b3bc1416c77c0ef0d75ef8d233d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1815ea317e21ccc9ee60dfa6a0f8b402 |
| publicationDate | 2009-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2323555-T3 |
| titleOfInvention | IMPROVED PROCEDURE FOR THE PREPARATION OF RAMIPRILE. |
| abstract | Procedure for preparing ramiprile of the formula (I): ** see formula ** characterized in that: (A) a compound of the formula (II) is saponified: ** see formula ** in which R means (C1-C4) alkyl ), in a suitable solvent, with the addition of one or more bases or acids to give a compound of the formula (III): and then (B) the compound of the formula (III) is reacted under the addition of penicillin G amidase to give a mixture of the compounds of the formulas (IV) and (V): or a mixture of salts of the compounds of the formula (IV) and (V), which are in equilibrium between them, and then (BA ' ') the compound of the formula (II) is reacted with penicillin G amidase and then saponified by the addition of one or more bases or acids to give a mixture of the compounds of the formulas (IV) and (V) or a mixture of salts of the compounds of the formula (IV) and (V), and then (C) the compound (V), or a salt of the compound (V) of the compound mixture is reacted (IV) and (V) or their salts, by catalytic hydrogenation, to give a compound of the formula (VI): ** see formula ** or one of its salts, and then (DA) the compound is reacted the formula (VI) with a compound of the formula (VII): ** see formula ** to give the compound of the formula (I), or alternatively (DB.1) the compound (VI) is reacted with benzyl alcohol to give a compound of the formula (VIII): ** see formula ** or one of its salts, and then (DB.2.1) the compound (VIII) is reacted well with a compound of the formula (VII ) to give a compound of the formula (X): ** see formula ** or, alternatively, (DB.2.2) the compound (VIII) is reacted with a compound of the formula (IX): ** see formula * * to give the compound (X), and then (DB.3) the compound of the formula (I) is formed from the compound (X) by catalytic hydrogenation. |
| priorityDate | 2005-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.