| abstract |
A compound, having the formula I, its tautomers, geometric isomers (including cis and trans isomers, Z and E), enantiomers, diastereoisomers and mixtures thereof (including all possible mixtures of stereoisomers), or pharmaceutically acceptable salts of the same, ** (See formula) ** wherein R1 is hydrogen, C1-20 alkyl, C3-8 cycloalkyl, halogen, hydroxy, alkoxy, aryloxy, ester, amido, cyano, nitro, amino, guanidine, a amino, alkylthio, arylthio, alkylsulfonyl, arylsulfonyl, alkylsulfinyl, arylsulfinyl, aryl or heterocycle derivatives; R2 is hydrogen, C1-20 alkyl, alkoxy, amino, halogen, hydroxy, ester, amido, nitro, cyano, carbamate, or aryl; R3 is hydrogen, C1-20 alkyl, alkoxy, amino, halogen, hydroxy, ester, amido, nitro, cyano, carbamate, or aryl; R4 is hydrogen, C1-20 alkyl, C2-12 alkenyl, C2-12 alkynyl, aryl, azido, alkoxycarbonylamino, arylsul-phyloxy or heterocycle; R4a is hydrogen or C1-20 alkyl; or R4 and R4a can together form a C3-8 cycloalkyl; R 5 is hydrogen; |