http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2321798-T3
Outgoing Links
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| filingDate | 2000-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70aac6a07e9ebd8704f738d4616688cb http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cb3d681b5d520d61951fdf88d4dcca21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c32a977ffcecc53e8c23a8b9d77bf4fc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_326ff7140701ed352a7d318a744cf5ff http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c9d577e929c4a22cfb67e4aaf557c8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_82ac47848137c22e71e3c6cf4775ab4f |
| publicationDate | 2009-06-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2321798-T3 |
| titleOfInvention | CHEMIOKIN RECEIVER ANTAGONISTS AND METHODS OF USE FOR THEMSELVES. |
| abstract | A compound that is a tertiary amine of the following formula: in which: n is one to four, M is> NR 2,> CR 1 R 2, -O-CR 1 R 2 -O- or -CH 2- CR 1 R 2 -O-; q 1 is zero to three; q 2 is zero or one; R 1 is -H, -OH, -N3, a halogen, an aliphatic group, a substituted aliphatic group, an aminoalkyl group, -O- (aliphatic group), -O- (substituted aliphatic group), -SH, -S - (aliphatic group), -S- (substituted aliphatic group), -OC (O) - (aliphatic group), -OC (O) - (substituted aliphatic group), -C (O) O- (aliphatic group), -C (O) O- (substituted aliphatic group), -COOH, -CN, -CO-NR 3 R 4, -NR 3 R 4 or R 1 is a covalent bond between the ring atom that is in M and a adjacent carbon atom in the ring containing M; R 2 is -OH, an acyl group, a substituted acyl group, -NR 5 R 6, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group, a substituted benzyl group, a group non-aromatic heterocyclic, a substituted non-aromatic heterocyclic group, -O- (substituted or unsubstituted aromatic group) or -O- (substituted or unsubstituted aliphatic group); R 3, R 4, R 5 and R 6 are independently -H, an acyl group, a substituted acyl group, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a benzyl group, a benzyl group substituted, a non-aromatic heterocyclic group or a substituted non-aromatic heterocyclic group; or R 1 and R 2, R 3 and R 4, or R 5 and R 6 taken together with the atom to which they are attached, form a carbocyclic or heterocyclic, non-aromatic, substituted or unsubstituted ring; Z is: where: where: X1 is -CH2-S-, -S-CH2-, -O-CH2-, -CH2-O-, -SO-CH2-, -CH2-SO-, -S (O) 2-CH2-, -CH2-S (O) 2- or a link; R 40 is -S (O 2) -NR 21 R 22, -NH-C (O) -NR 21 R 22, -OC (O) -NR 21 R 26, said substituted aliphatic group comprises one or more substituents selected from the group consisting of an electron removal group, halo, azido, -COOH, -OH, -CONR 24 R 25, -NR 24 R 25, -OS (O) 2NR 24 R 25, -S (O) 2NR 24 R 25, -SO3H, -S (O) 2NH2, guanidino, - (O) u- (CH2) tC (O) OR 20, - (O) u- (CH2) t-OC (O) R 20, - (O) u- (CH2) tC (O) -NR 21 R 22, (O) u- (CH2) t-NHC (O) OR 20, -QH, -Q- (aliphatic group), -Q- (substituted aliphatic group), -Q- (aryl), -Q- (aromatic group), -Q- (substituted aromatic group), -Q- (CH2) p- (substituted or unsubstituted aromatic group), -Q- (non-aromatic heterocyclic group), -Q- (CH 2) p- (non-aromatic heterocyclic group), oxo, epoxy, non-aromatic heterocycle, benzyl, substituted benzyl, an aromatic group and a substituted aromatic group; said substituted benzyl group and said substituted aromatic group comprise one or more substituents selected from the group consisting of an electron removal group, halo, azido, -CN, -COOH, -OH, -CONR 24 R 25, -NR 24 R 25, -OS (O) 2NR 24 R 25, -S (O) 2NR 24 R 25, -SO 3H, -S (O) 2NH 2, guanidino, - (O) u- (CH 2) tC (O ) OR 20, - (O) u- (CH 2) t-OC (O) R 20, - (O) u- (CH2) tC (O) -NR 21 R 22, - (O) u- (CH2 ) t-NHC (O) OR 20, -QH, -Q- (aliphatic group), -Q- (substituted aliphatic group), -Q- (aryl), -Q- (aromatic group), -Q- (group substituted aromatic), -Q- (CH2) p- (substituted or unsubstituted aromatic group), -Q- (non-aromatic heterocyclic group), -Q- (CH2) p- (non-aromatic heterocyclic group), an aliphatic group and a substituted aliphatic group; said substituted non-aromatic heterocyclic group comprises one or more substituents selected from the group consisting of an electron removal group, halo, azido, -CN, -COOH, -OH, -CONR 24 R 25, -NR 24 R 25, -OS (O) 2NR 24 R 25, -S (O) 2NR 24 R 25, -SO3H, -S (O) 2NH2, guanidino, - (O) u- (CH2) tC (O) OR 20, - ( O) u- (CH2) tOC (O) R 20, - (O) u- (CH 2) tC (O) -NR 21 R 22, - (O) u- (CH 2) t-NHC (O) OR 20, -QH, -Q- (aliphatic group), -Q- (substituted aliphatic group), -Q- (aryl), -Q- (aromatic group), -Q- (substituted aromatic group), -Q- (CH 2) p- (substituted or unsubstituted aromatic group), -Q- (non-aromatic heterocyclic group), -Q- (CH2) p- (non-aromatic heterocyclic group), an aliphatic group, a substituted aliphatic group, = O, = S, = NH, = N (aliphatic), = N (aromatic) and = N (aromatic substituted); R 20, R 21 and R 22 are independently -H, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a non-aromatic heterocyclic group, -NHC (O) -O- (aliphatic group), -NHC (O) -O- (aromatic group) or -NHC (O) -O- (non-aromatic heterocyclic group); R 26 is -H, an aliphatic group, a substituted aliphatic group, an aromatic group, a substituted aromatic group, a non-aromatic heterocyclic group, -C (O) -O- (substituted or unsubstituted aliphatic group), -C ( O) -O- (substituted or unsubstituted aromatic group), -S (O) 2- (substituted or unsubstituted aliphatic group), -S (O) 2-substituted or unsubstituted aromatic group; or R 21 and R 22, taken together with the nitrogen atom to which they are attached, form a non-aromatic heterocyclic ring; or R 21 taken together with R 26 and the nitrogen atom to which they are attached form a heterocyclic, non-aromatic, substituted or unsubstituted ring; R 23 is -H, an aliphatic group, a benzyl group, an aryl group or a non-aromatic heterocyclic group; R 24 and R 25 are independently -H, -OH, an aliphatic group, a substituted aliphatic group, a benzyl group, an aryl group or a non-aromatic heterocyclic group; t is zero to three; u is zero or one; p is one to five; Q is -O-, -S-, -S (O) -, -S (O) 2-, -OS (O) 2-, -C (O) -, -OC (O) -, -C ( O) O-, -C (O) C (O) -O-, -OC (O) C (O) -, -C (O) NH-, -NHC (O) -, -OC (O) NH -, -NHC (O) O-, -NH-C (O) -NH-, -S (O) 2NH-, -NHS (O) 2-, -N (R 23) -, -C (NR 23 ) NHNH-, -NHNHC (NR 23) -, -NR 24 C (O) - or -NR 24 S (O) 2-; said aminoalkyl group is a C 1 to C 12 alkyl group substituted with -NR 24 R 25; said aliphatic group is a saturated or unsaturated C1-C20 hydrocarbon; said electron withdrawal group is alkylimino, alkylsulfonyl, carboxamido, alkyl carboxylic ester, -CH = NH or -NO 2; said acyl group is aliphatic carbonyl, aromatic carbonyl, aliphatic sulfonyl or aromatic sulfonyl; said substituted acyl group is substituted aliphatic carbonyl, substituted aromatic carbonyl, substituted aliphatic sulfonyl or substituted aromatic sulfonyl; the heterocycle of said non-aromatic heterocyclic group is a 5- to 8-membered non-aromatic ring containing one or more heteroatoms selected from the group consisting of O, N and S; and said aromatic group is selected from the group consisting of a C6 aromatic carbocycle, a C5-C6 aromatic heterocycle comprising one or more heteroatoms selected from the group consisting of O, S and N, and a C6 aromatic carbocycle or a heterocycle C5-C6 aromatic which is condensed with one or more different rings; or a physiologically acceptable salt thereof. |
| priorityDate | 1999-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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