| abstract |
An undifferentiated collection of human antibody polypeptides, in which all functional members comprise a VH domain comprising a hypervariable loop having the canonical structure of the H1 hypervariable loop encoded by the DP-47 segment of the VH gene of the human germline, wherein said loop is diversified by changing said loop in one or more positions that are selected from the group consisting of H31, H33 and H35. |