http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2319970-T3
Outgoing Links
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| filingDate | 2002-09-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_206a2ef8d3b0851d602fa55d9f5e1555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85e1ddfd3a9d26f7fad7df9bc22cdd24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c790d8f6f0367f7b04e586aa42a6c10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aac1da39e982292838cba0428c48b0ab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_95f40221761e4ae2d1252ac8d8f2149c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dc3a69f397669ad712f81bb3175791b0 |
| publicationDate | 2009-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2319970-T3 |
| titleOfInvention | DERIVATIVES OF INVESTED HYDROXAMIC ACID. |
| abstract | A reverse hydroxamic acid derivative represented by the general formula (Ia) or one of its salts ** see formula ** [wherein A is a hydrogen atom, C 1-6 alkyl, a cycloalkyl or -NR 3 R 4 (in where R 3 and R 4 are independently a hydrogen atom, a C 1-6 alkyl or a cycloalkyl, or form a nitrogen-containing heterocycle together with the nitrogen to which R 3 and R 4 bind); Ar 1 is an arylene or a heteroarylene; Ar 2 is an optionally substituted aryl, an optionally substituted aralkyl, an optionally substituted heteroaryl or an optionally substituted heteroarylalkyl; R 1 is a hydrogen atom, an optionally substituted C 1-6 alkyl, a C 1-6 alkenyl having one or more optionally substituted double bonds or an optionally substituted cycloalkyl; R 2a is represented by the general formula (a): ** see formula ** (where R 5 and R 6 are independently a hydrogen atom, a halogen atom, hydroxyl, cyano, trifluoromethyl, a C 1-6 alkyl optionally substituted or an optionally substituted C 1-6 alkoxy; R 68 and R 69 are independently a hydrogen atom or an optionally substituted C1-6 alkyl; X 1 and Y 1 are independently a single bond, oxygen, sulfur, -CR 7 R 8 - (where R 7 and R 8 are independently equal to R 5) or -NR 9 - (where R 9 is a hydrogen atom or an optionally substituted C1-6 alkyl, an optionally substituted aryl or an optionally heteroaryl substituted); Z 1 is oxygen, sulfur, = CR 10 R 11 (where R 10 and R 11 are independently a hydrogen atom, a halogen atom, cyano, trifluoromethyl, an optionally substituted C 1-6 alkyl, carboxyl, -CONR 12 R 13 (where R 12 and R 13 are independently a hydrogen atom, an alkyl C1-6 yl or a cycloalkyl, or form a nitrogen-containing heterocycle together with the nitrogen to which R 12 and R 13 are attached), -COR 14 (where R 14 is a hydrogen atom, a C 1-6 alkyl optionally substituted, an optionally substituted C 1-6 alkoxy, an optionally substituted aryl, an optionally substituted aralkyl, an optionally substituted heteroaryl or an optionally substituted heteroarylalkyl), = NR 15 (wherein R 15 is a hydrogen atom, hydroxyl, a optionally substituted C1-6 alkyl, an optionally substituted C1-6 alkoxy or an optionally substituted acyl), -O (CH2) p1O- (where p 1 is an integer from 2 to 4), -S (CH2) r1S- (where r 1 is an integer from 2 to 4) or -O (CH2) t1S- (where t 1 is an integer from 2 to 4); m 1 is an integer from 0 to 6; n 1 and q 1 are independently an integer from 0 to 3; and v 1 is 0 or 1), by the general formula (b): ** see formula ** (where R 16 is a hydrogen atom, a halogen atom, hydroxyl, cyano, trifluoromethyl, a C1-6 alkyl optionally substituted or an optionally substituted C1-6 alkoxy; R 17 is a hydrogen atom, a halogen atom, or an optionally substituted C1-6 alkyl; R 70 and R 71 are independently a hydrogen atom or a C 1-6 alkyl optionally substituted; X 2 and Y 2 are independently a single bond, oxygen, sulfur, -CR 18 R 19 - (where R 18 is a hydrogen atom, a halogen atom, an optionally substituted C1-6 alkyl or an alkoxy Optionally substituted C1-6, and R 19 is a hydrogen atom, a halogen atom, hydroxyl, cyano, trifluoromethyl, an optionally substituted C1-6 alkyl, an optionally substituted C1-6 alkoxy, an optionally substituted acyl, carboxyl, - CONR 20 R 21 (where R 20 and R 21 are independently a hydrogen atom, an al C 1-6 chyl or a cycloalkyl, or form a nitrogen-containing heterocycle together with the nitrogen to which R 20 and R 21 are attached), -SO 2 R 22 (wherein R 22 is a C 1-6 alkyl, a cycloalkyl, a optionally substituted aryl or an optionally substituted heteroaryl), -NR 23 R 24 (wherein R 23 and R 24 are independently a hydrogen atom, an optionally substituted C1-6 alkyl, formyl, an optionally substituted acyl, a C1-6 alkylsulfonyl , an optionally substituted arylsulfonyl, an optionally substituted heteroarylsulfonyl, -CONR 25 R 26 (wherein R 25 and R 26 are independently a hydrogen atom, an optionally substituted C 1-6 alkyl, an optionally substituted aryl or an optionally substituted heteroaryl, or form a nitrogen-containing heterocycle together with the nitrogen to which R 25 and R 26 are attached, or a cycloalkyl, or form a nitrogen-containing heterocycle together with the nitrogen to which R 23 and R 2 are attached 4), or -OCOR 27 (wherein R 27 is an optionally substituted C1-6 alkyl, an optionally substituted aryl, an optionally substituted heteroaryl or -NR 28 R 29 (wherein R 28 and R 29 are independently a hydrogen atom , an optionally substituted C1-6 alkyl, an optionally substituted aryl or an optionally substituted heteroaryl, or form a nitrogen-containing heterocycle together with the nitrogen to which R 28 and R 29 are attached))), or -NR 30 - (in where R 30 is a hydrogen atom, an optionally substituted C1-6 alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, -COR 31 (where R 31 is a hydrogen atom, an optionally substituted C 1-6 alkyl or an optionally substituted C 1-6 alkoxy) or -CONR 32 R 33 (wherein R 32 and R 33 are independently a hydrogen atom, a C 1-6 alkyl or a cycloalkyl, or form a nitrogen-containing heterocycle together with the nitrogen to which R 32 and R 33 are attached )); Z 2 is two hydrogen atoms, oxygen, sulfur, = CR 34 R 35 (where R 34 and R 35 are independently a hydrogen atom, a halogen atom, cyano, trifluoromethyl or an optionally substituted C 1-6 alkyl, an optionally substituted acyl, carboxyl, -CONR 36 R 37 (wherein R 36 and R 37 are independently a hydrogen atom, a C1-6 alkyl or a cycloalkyl, or form a nitrogen-containing heterocycle together with the nitrogen to which they are joined R 36 and R 37)), = NR 38 (where R 38 is a hydrogen atom, hydroxyl, an optionally substituted C1-6 alkyl, an optionally substituted C1-6 alkoxy or an optionally substituted acyl), -O ( CH 2) p2O- (where p 2 is an integer from 2 to 4), -S (CH 2) r2S- (where r 2 is an integer from 2 to 4) or -O (CH 2) t2S - (where t 2 is an integer from 2 to 4); m 2 is an integer from 0 to 6; n 2 and q 2 are independently an integer from 0 to 3, and v 2 is 0 or 1), by the general formula (c): ** see formula ** (where G 1 is an unsaturated ring of four to seven members optionally substituted with 1 to 4 independent R 39 in an optional position; R 39 is hydroxyl, a halogen atom, cyano, trifluoromethyl, an optionally substituted C1-6 alkyl, an optionally substituted C1-6 alkoxy, an optionally substituted acyl, carboxyl , -CONR 40 R 41 (where R 40 and R 41 are independently a hydrogen atom, a C1-6 alkyl or a cycloalkyl, or form a nitrogen-containing heterocycle together with the nitrogen to which R 40 and R 41 are attached ), -SO2R 42 (where R 42 is a C 1-6 alkyl, a cycloalkyl, an optionally substituted aryl or an optionally substituted heteroaryl), -NR 43 R 44 (where R 43 and R 44 are independently an atom of hydrogen, an optionally substituted C1-6 alkyl, formyl, an optionally substituted acyl C, a C 1-6 alkylsulfonyl, an optionally substituted arylsulfonyl, an optionally substituted heteroarylsufonyl, -CONR 45 R 46 (wherein R 45 and R 46 are independently a hydrogen atom, an optionally substituted C 1-6 alkyl, an optionally aryl substituted or an optionally substituted heteroaryl, or form a nitrogen-containing heterocycle together with the nitrogen to which R 45 and R 46 are attached or a cycloalkyl, or form a nitrogen-containing heterocycle together with the nitrogen to which R 43 and R 44), or -OCOR 47 (wherein R 47 is an optionally substituted C1-6 alkyl, an optionally substituted aryl, an optionally substituted heteroaryl or -NR 48 R 49 (wherein R 48 and R 49 are independently an atom of hydrogen, an optionally substituted C 1-6 alkyl, an optionally substituted aryl or an optionally substituted heteroaryl, or form a nitrogen-containing heterocycle together with the nitrogen to which they are attached two R 48 and R 49)); and m 3 is an integer from 0 to 6), by the general formula (da): ** see formula ** (where G 2a is an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted cycloalkyl or an optionally heterocycloalkyl substituted, each of which is substituted with R 50 in an optional position (R 50 is an optionally substituted C1-6 alkyl or an optionally substituted C1-6 alkenyl having one or more double bonds); and m 4 is an integer from 0 to 6), for the general formula (e): ** see formula ** (where R 51 is -CR 72 = CR 73 -, -C = C- or -CR 74 R 75 -CR 76 R 77 - (wherein R 72, R 73, R 74, R 75, R 76 and R 77 are independently a hydrogen atom or an optionally substituted C 1-6 alkyl); R 52 is an optionally substituted aryl, an optionally substituted aralkyl , an optionally substituted heteroaryl, an optionally substituted heteroarylalkyl, an optionally substituted cycloalkyl, a cycloalkyl optionally substituted ylalkyl, an optionally substituted heterocycloalkyl, an optionally substituted heterocycloalkenyl, an optionally substituted heterocycloalkylalkyl or an optionally substituted heterocycloalkenyl alkyl; and m 5 is an integer from 0 to 6), or by the general formula (f): ** see formula ** (where R 6, R 68, R 69, X 1, Y 1, Z 1, n 1 , q 1 and v 1 are the same as defined above; and m 6 is an integer from 1 to 6), where - the at least one substituent of the ar |
| priorityDate | 2001-09-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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