http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2319555-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_34bd4e87ecbca17f16d460ca394e60f9 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4453 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-5377 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
| filingDate | 2005-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f490a0361cea5d7f702f07bff570a27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da8c3b37ca5b38a52a7f36663f21e60e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e8bba50f9909cea2d5780568aaa7c75a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2278a6e527a05d48c996c2f1c2fcd8f8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b510fab1c7d0a848665feb680f39eb64 |
| publicationDate | 2009-05-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2319555-T3 |
| titleOfInvention | 2,5-DIAMINOMETIL-1H-PIRROLES REPLACED. |
| abstract | 2,5-diaminomethyl-1H-substituted pyrroles of the general formula I below ** see formula ** R 1 and R 2, together with the nitrogen atom that binds them as a ring member, form a saturated or unsaturated cycloaliphatic group that optionally it presents at least one other heteroatom as a ring member and that can be substituted in a single or multiple way, the same or different, with substituents selected from the group consisting of (C1-5) alkyl, -C (= O) -O- (C1-5) alkyl, -O-(C1-5) alkyl, Cl, F, Br, I, -C (= O) (C1-5) alkyl, -NH2, -NH-(C1-5) alkyl , -N ((C1-5) alkyl) 2, furanyl, if at least simply substituted, thiophenyl, if necessary, at least simply substituted, pyridinyl, if given, substituted at least simply, phenyl, if appropriate replaced at least in a simple way and benzyl if necessary replaced at least in a simple way; the corresponding furanyl, thiophenyl, pyridinyl, phenyl or benzyl substituent may itself not be substituted or substituted in turn, in a single or multiple way, with substituents selected, independently from each other, from the group consisting of hydroxyl, F, Cl , Br, I, -NH 2, -NH-(C 1-5) alkyl, -N ((C 1-5) alkyl) 2, -NO 2, -CN, -CF 3, -CHF 2, -CH2F , (C1-5) alkyl and (C1-5) alkoxy; R 3 represents a linear or branched, saturated or unsaturated aliphatic group, substituted at least simply or unsubstituted; R 4 represents a hydrogen group; a linear or branched aliphatic group, substituted at least simply or unsubstituted, saturated or unsaturated; a saturated or unsaturated cycloaliphatic group, substituted at least in a simple or unsubstituted manner, which, if necessary, has at least one heteroatom as a ring member and which may be linked through a linear or branched alkylene group; or at least one simple or unsubstituted substituted aryl group linked through a linear or branched alkylene group; R 5 represents a linear or branched aliphatic group, substituted at least simply or unsubstituted, saturated or unsaturated; a saturated or unsaturated cycloaliphatic group, substituted at least in a simple or unsubstituted manner, which, if necessary, has at least one heteroatom as a ring member and which may be linked through a linear or branched alkylene group; or at least one simple or unsubstituted substituted aryl group linked through a linear or branched alkylene group; or R 4 and R 5, together with the nitrogen atom that binds them as a ring member, form a saturated or unsaturated cycloaliphatic group that eventually has at least one other heteroatom as a ring member and that can be substituted in a single or multiple way, same or different, with substituents selected from the group consisting of (C1-5) alkyl, -C (= O) -O-C1-5 alkyl, -O-(C1-5) alkyl, Cl, F, Br, I, -C (= O) -C1-5 alkyl, -NH2, -NH-C1-5 alkyl, -N (C1-5 alkyl) 2, furanyl if necessary substituted at least in a simple way, thiophenyl if at least substituted in a simple way, pyridinyl in a given case replaced at least in a simple way, phenyl in a given case substituted at least in a simple way and benzyl in a given case replaced at least in a simple way; the corresponding furanyl, thiophenyl, pyridinyl, phenyl or benzyl substituent may itself be unsubstituted or substituted in turn simply or multiplely with substituents selected, independently from each other, from the group consisting of hydroxyl, F, Cl, Br , I, -NH 2, -NH-(C 1-5) alkyl, -N ((C 1-5) alkyl) 2, -NO 2, -CN, -CF 3, -CHF 2, -CH 2F, (C 1-5) alkyl and (C 1-5) alkoxy; the aforementioned aliphatic groups may be substituted with substituents selected, independently from each other, from the group consisting of halogen, hydroxyl, -CN, -CF3, -CHF2, -CH2F, (C1-6) alkoxy and phenyl if substituted at least simply, whose substituents can be selected, in each case independently from each other, from the group consisting of hydroxyl, F, Cl, Br, I, -NH 2, -NH-alkyl (C 1-5), -N ((C1-5) alkyl) 2, -NO2, -CN, -CF3, -CHF2, -CH2F, (C1-5) alkyl and (C1-5) alkoxy; the above-mentioned aryl groups may be substituted with substituents selected, independently from each other, from the group consisting of (C1-5) alkyl, -C (= O) -O-(C1-5) alkyl, -O-alkyl ( C1-5), Cl, F, Br, I, -C (= O) -C1-5 alkyl, -NH2, -NH-C1-5 alkyl, -N (C1-5 alkyl) 2, furanyl, if necessary, substituted at least simply, thiophenyl, if given, substituted at least in a simple way, pyridinyl, if given, substituted at least in a simple way, phenyl, if necessary, substituted at least, simply and benzyl, if appropriate replaced at least simply; the corresponding furanyl, thiophenyl, pyridinyl, phenyl or benzyl substituent may itself be unsubstituted or substituted in turn simply or multiplely with substituents selected, independently from each other, from the group consisting of hydroxyl, F, Cl, Br , I, -NH2, -NH-(C 1-5) alkyl, -N ((C 1-5) alkyl) 2, -NO 2, -CN, -CF 3, -CHF 2, -CH 2F, alkyl (C 1-5) and alkoxy (C 1-5); the above-mentioned cycloaliphatic groups may be substituted at the positions of the R 4 and R 5 groups with substituents selected, independently from each other, from the group consisting of (C1-5) alkyl, -C (= O) - O-alkyl (C 1-5), -O-alkyl (C 1-5), Cl, F, Br, I, -C (= O) -alkyl (C 1-5), -NH 2, -NH-alkyl ( C 1-5), -N ((C 1-5) alkyl) 2, furanyl, if at least simply substituted, thiophenyl, if necessary, at least simply substituted, pyridinyl, if at least substituted, at least simple, phenyl, if any, substituted at least simply, and benzyl, if necessary, substituted at least, simply; the corresponding furanyl, thiophenyl, pyridinyl, phenyl or benzyl substituent may itself not be substituted or in turn substituted with substituents selected, independently from each other, from the group consisting of hydroxyl, F, Cl, Br, I, -NH 2, -NH-(C1-5) alkyl, -N ((C1-5) alkyl) 2, -NO2, -CN, -CF3, -CHF2, -CH2F, (C1-5) alkyl and (C1-) alkoxy 5); if it is the case optionally in the form of its pure stereoisomers, in particular enantiomers or diastereoisomers, in the form of racemates or in the form of stereoisomers, in particular of enantiomers and / or diastereoisomers, in any mixing ratio, or in each case in the form of the corresponding salts or in each case in the form of the corresponding solvates; excluding compounds of general formula I in which groups R 1 and R 2 and groups R 4 and R 5, in each case together with the nitrogen atom that binds them as a ring member, form the same group selected from between pyrrolidinyl, morpholinyl and piperidinyl, and the group R 3 represents in each case a methyl group; and also the compounds of general formula I in which the groups R 1 and R 2, together with the nitrogen atom that binds them as a ring member, form a piperidinyl group, and the groups R 3 to R 5 represent in each case a methyl group. |
| priorityDate | 2004-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 229.