| abstract |
Orodispersible effervescent tablet comprising: - a mixture of excipients comprising at least one disintegrating agent selected from croscarmellose, crospovidone and its mixture, a soluble diluting agent, a lubricating agent and possibly an internal dehydrating agent, a swelling agent, an agent permeabilizer, sweeteners, aromas and dyes, - and effervescent granules based on at least one coated active ingredient and a mixture consisting of an acidic agent, a hot extrudable binder and an alkaline agent and possibly a dehydrating agent and a lubricant, being prepared said granules by hot extrusion in the absence of water and solvents, and said tablet disintegrating in the oral cavity upon contact with the saliva in less than 60 seconds and preferably in less than 40 seconds. |