http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2318927-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aff6633139e8f79659a0587cc38a6c07 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J75-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07J41-0055 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-575 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07J75-00 |
| filingDate | 2005-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2010-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e082174f2995d1bbb0551d88d6dd81d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5576d4073f967256534bedf0126cda7f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8eb98aa30d7db98d5156dac0fd00a76f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7a1c8c5cf01e54ac51e6da84ed4f20c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad94158808d9dd38b3fcc05d9369c715 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a8d8b927fa8500a20a1fc47f58685f4d |
| publicationDate | 2010-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2318927-B1 |
| titleOfInvention | NEW DIMEROS OF BILIAR ACIDS FUNCTIONED IN POSITION 24 OF THE ALQUILICA CHAIN OF THE BILIARY SALT. PROCEDURES FOR OBTAINING AND APPLICATIONS. |
| abstract | New dimers of functionalized bile acids at position 24 of the alkyl chain of bile salt. Procedures for obtaining and applications. The new compounds result from the conjugation of 24-amino derivatives of natural bile acids, colic, deoxycholic, ursodeoxycholic, chenodeoxycholic and lithocolic acid with activated acidic compounds that act as a bridge between the two steroids. The bridges used are those derived from the compounds: N, N'-1,2-ethanediylbis [N (carboxymethyl), 1,1'-dimethyl ester] glycine; 1,4-dimethyl ester-1,2,4,5-benzene tetracarboxylic acid; 1,5-dimethyl ester-1,2,4,5-benzenetetracarboxylic acid; Y N, N-bis [2- (2,6-dioxo-4-morpholinyl) ethyl] glycine. The procedures used for the preparation of the above derivatives consist of reactions; (1) of the amino group of bile acid with an acid chloride; (2) of the amino group of bile acid with an acid activated with species such as DEPC or HOBt / DCC or DIC; and (3) of the amino group of bile acid with an anhydride. From the synthesized acids, the sodium and potassium salts are obtained. |
| priorityDate | 2005-08-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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