http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2318503-T3
Outgoing Links
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|---|---|
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D513-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D263-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F7-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-42 |
| filingDate | 2005-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dea9b1bacecf69ec8506a8241e7449e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_007493d96afbb17eebf64fd83d034f50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e635fa259947b3ee605e23342eacbc37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ab905b259781e5b99f12ec9d9c07ba7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7f4647544aeeb078c9055d4748616eb5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3ac70350c8e1ea47d0da17535913f7ec |
| publicationDate | 2009-05-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2318503-T3 |
| titleOfInvention | INHIBITORS OF 11-BETA-HYDROXIESTEROID DEHYDROGENASE TYPE 1. |
| abstract | A compound of general formula (III) ** see formula ** in which R5 is phenyl- (CR 10a R 10a) 1-3- optionally substituted; and wherein R 10a is independently selected from H, methyl, fluoro or R 10a and R 10a can be combined together to form a C3-6 cycloalkyl ring; R 6 is selected from C 1-8 alkyl, C 1-8 alkoxy, C 3-10 cycloalkyl, heterocyclyl, C 3-10 cycloalkyl, C 1-8 alkyl, aryl, C 1-8 arylalkyl ; C 1-8 heterocyclylalkyl and haloalkyl; R 7 is selected from -NR 8 R 9, halo, C 1-8 alkyl, - (CR 8 R 9) n-OR 8, -S-C 1-8 alkyl, C 3-10 cycloalkyl, heterocyclyl, C 3-10 cycloalkyl -C 1-8 alkyl, C 1-8 cyanoalkyl, aryl, C 1-8 arylalkyl, C 1-8 heterocyclylalkyl, heterocyclyl-C (O) -C 1-8 alkyl, heterocyclyl-SO 2-C 1-8 alkyl , C 1-8 haloalkyl, R 8 R 9 N-C 1-8 alkyl, HO-C 1-8 alkyl, -C (O) C 3-10 cycloalkyl, -C (O) -C 1-8 haloalkyl, - ( CR 8 R 9) nY- (CR 8 R 9) n-heterocyclyl and - (CR 8 R 9) nY- (CR 8 R 9) nC (O) - R 8 (where n is 0-5, Y is NR 10, O or S); wherein any aryl, alkyl, heterocyclyl or cycloalkyl residue is optionally substituted with one or more of -C 1-8 alkyl, -halo, -OH, -OR 10, -C 1-8 alkyl-SO2-, -SO 2-aryl , -C (O) - (CR 8 R 9) n-carbamate, -C (O) -O-C 1-8 alkyl, -C (O) -C 1-8 alkyl, -C (O) - (CR 8 R 9) nC (O) -NR 8 R 9, -C (O) - (CR 8 R 9) n-NR 8 -C (O) -C 1-8 alkyl, -C (O) - (CR 8 R 9) n-NR 8 R 9, -C (O) -C 3-10 cycloalkyl, -C (O) -aryl, -C (O) - (CR 8 R 9) n-heterocyclyl, -C1 alkyl -8-OR 8, -C (O) -C 1-8 haloalkyl or -C (O) - (CR 8 R 9) n-aryl, wherein any aryl, alkyl, cycloalkyl or heterocyclyl residue is optionally independently substituted with one or more of C 1-8 alkyl, aryl, halogen, -NR 10 R 10, C 1-8 haloalkyl, HO-C 1-8 alkyl, R 8 R 9 N-C 1-8 alkyl, C 1- alkyl 8-OR 10, -OR 10, C 3-10 cycloalkyl or C 1-8 alkyl sulfonyl, -O- (CR 8 R 9) n-heterocyclyl, -O- (CR 8 R 9) nC (O) - NR 8 R 9, -O- (CR 8 R 9) n-NR 8 R 9, -Y- (CR 8 R 9) n-NR 8 -C (O) -C1-8 alkyl, -Y- (CR 8 R 9) n-he terticyclyl, -O- (CR 8 R 9) nNR 8 R 9 or C1-8-SO2 alkyl; wherein R 8 and R 9 are each independently selected from hydrogen, C 1-8 alkyl, C 1-8 alkoxy, -NR 10 R 10, -S-C 1-8 alkyl, aryl and heterocyclyl; any alkyl, alkoxy, heterocyclyl or aryl may be substituted with one to three substituents selected from halo, unsubstituted C 1-8 alkyl, unsubstituted C 1-8 alkoxy, unsubstituted C 1-8 thioalkoxy and non-C 1-4 arylalkyl replaced; wherein R 10 is independently selected from hydrogen, C 1-8 alkyl, C 1-8 aryl-alkyl, C 1-8 alkoxy, C 1-8 alkyl, heterocyclyl and aryl; any heterocyclyl or aryl may be substituted with one to three substituents selected from halo, unsubstituted C1-8 alkyl, unsubstituted C1-8 alkoxy, unsubstituted C1-8 thioalkoxy and unsubstituted C1-4 arylalkyl; or R 6 and R 7 together with the carbon atom attached thereto a saturated C3-10 cycloalkyl, partially unsaturated or unsaturated, or a saturated C 4-14 heterocyclyl, partially unsaturated or unsaturated; wherein the cycloalkyl or heterocyclyl may be optionally substituted with one or more of C1-8 alkyl, aryl, haloalkyl C1-8, arylalkyl C1-8, cycloalkyl C3-10, -OR 8, = O, = NR 8, = N-OR 8, -NR 8 R 9, -SR 8, -halo, -OC (O) R 8, -C (O) R 8, -CO2R 8, -CONR 8 R 9, -OC (O) NR 8 R 9, -NR 9 C (O) R 8, NR 8 C (O) NR 8 R 9, -NR 8 SO2NR 8 R 9), -NR 8 CO2R 9, -NHC (NH 2) = NH, -NR 8 C (NH 2 = NH), -NHC (NH 2) NR 8, -S (O) R 8, -SO 2R 8, -SO 2NR 8 R 9, -NR 8 SO 2R 9, -CN and -NO 2; and pharmaceutically acceptable salts, solvates, hydrates, geometric isomers, tautomers, optical isomers and N-oxides thereof, with the proviso that: when R 6 = R 7 = methyl, then R 5 is not phenyl or 4-iodophenyl, R 6 = R 7 = phenyl, then R 5 is not phenyl and R 6 and R 7 combine to form a cyclopropyl ring, then R 5 is not n-butyl, cyclohexyl, benzyl, phenyl or naphthyl. |
| priorityDate | 2004-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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Total number of triples: 1219.