| abstract |
A compound of formula ** see formula ** in which m is 0, 1, 2 or 3 p is 1, 2, 3 or 4 R 3 is selected from the group consisting of alkyl, alkenyl, alkynyl, aryl and heterocyclyl; R 5 is selected from the group consisting of hydrogen, alkyl, aryl, heterocyclyl, alkoxycarbonyl, aryloxycarbonyl, heterocyclyloxycarbonyl, aminocarbonyl, alkylcarbonyl, arylcarbonyl, heterocyclylcarbonyl, alkylsulfonyl, arylsulfonyl and heterocyclylsulfonyl; R 8 is selected from the group consisting of unsubstituted alkyl, substituted alkyl, aryl and heterocyclyl; R 10 and R 11 are independently selected from the group consisting of hydrogen and C 1-4 alkyl; or its pharmaceutically acceptable salts or stereoisomers in which the IC 50 value of the compound is less than or equal to 25 µM in relation to the kinesin spindle protein. |