http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2317238-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709 |
| filingDate | 2005-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8127aae89225ba512692b270e73c50d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5c15e9b8b5f44d1f23eba096d1017c07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b73ef33a1f246a4049f069100961ab96 |
| publicationDate | 2009-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2317238-T3 |
| titleOfInvention | QUINOLINA-TIAZOLINONAS WITH ANTIPROLIFERANT ACTIVITY CDK-1. |
| abstract | A compound of the formula I ** see formula ** in which R 1 is hydrogen, C 1-6 alkyl, cycloalkyl, aryl-C 1-6 alkyl, C 1-6 alkoxy, hydroxy-C 1-6 alkyl, -NH 2, - [CH 2 CH 2 O ] vR8 or R2- (X) n-; X is selected from C 1-6 alkylene, cycloalkylene, C 1-6 aryl-alkylene, C 1-6 carboxy-alkylene, C 1-6 hydroxy-alkylene, C1-6 amido-alkylene, mono- or di-halo- C1-6 alkylene, C1-6 amino-alkylene, mono- or di (C1-6 alkyl) -C 1-6 amino-alkylene and C1-6 imido-alkylene; R 2 is ** see formula ** an aryl ring, is chosen from a cycloalkyl ring containing 3 to 6 carbon atoms, a heterocycloalkyl ring of 4 to 6 links containing 3 to 5 carbon atoms and 1 to 2 heteroatoms chosen from the group consisting of oxygen, nitrogen and sulfur and a heteroaromatic ring of 5 or 6 links containing 1 or 2 heteroatoms chosen from the group consisting of oxygen, sulfur and nitrogen; R 5, R 6 and R 7 are independently selected from each other from the group consisting of hydroxy, (C 1-6 alkyl) -sulfone, C 1-6 hydroxyalkyl, hydrogen, C 1-6 alkyl, halogen, perfluoro-alkyl C 1-6, C 1-6 alkoxy, amino, mono- or di- (C1-6 alkyl) amino or when two of the substituents R5, R6 and R7 are substituted at adjacent carbon atoms of the P ring, these two substituents they can be taken together with the adjacent carbon atom to which they are attached to form an aryl ring, a 3 to 6 link cycloalkyl ring, a 4 to 6 link heterocycloalkyl ring or a 4 to 6 link heteroaromatic ring, said heterocycloalkyl ring and said heteroaromatic ring contains 1 or 2 heteroatoms chosen from the group consisting of oxygen, nitrogen and sulfur; ** see formula ** is chosen from an aryl ring, a cycloalkyl ring containing 3 to 6 carbon atoms, a heterocycloalkyl ring of 4 to 6 links containing 1 or 2 heteroatoms chosen from the group consisting of oxygen, sulfur and nitrogen and a 5 or 6 link heteroaromatic ring containing 1 or 2 heteroatoms chosen from the group consisting of oxygen, sulfur and nitrogen; ** see formula ** R8, R11, R15, R16, R17 and R18 independently of each other are hydrogen or C1-6 alkyl; R 10 R12 R14 is C 1-6 alkyl; it is O or S; it is chosen from hydroxyalkyl, C1-6 alkyl, cycloalkyl, haloalkyl, perfluoralkyl and protected hydroxyalkyl; x, n and k are integers from 0 to 1; z is an integer from 0 to 3; and v is an integer from 1 to 3; and is an integer from 1 to 6, or N-oxides of the above compounds, in which R 2 contains a nitrogen atom in the heterocycloalkyl ring or heteroaromatic ring, and sulfones in R 2 contain a sulfur in the heterocycloalkyl ring or in the heteroaromatic ring; or pharmaceutically acceptable salts thereof. |
| priorityDate | 2004-07-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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