| abstract |
A compound of formula I ** see formula ** and its pharmaceutically acceptable salts, in which; (a) R3 is hydrogen; (b) R4 is hydrogen; (c) R5 is selected from (C1-C6) alkyl, (C1-C6) alkenyl, aryl (C0-C4) alkyl, aryloxy (C0-C4) alkyl, arylthio (C0-C4) alkyl, wherein said aryl (C0-C4) alkyl, aryloxy (C0-C4) alkyl and arylthio (C0-C4) alkyl are each independently and optionally substituted with one to three substituents, each independently selected from R5 ''; (d) R5 '' are each independently selected from halo, - (O) -alkyl (C1-C5) COOH, C1-C5 alkyl, C1-C5COOH and CF3; (e) R6 is selected from pyridinyl, pyrimidinyl and pyrazinyl, wherein said pyridinyl, pyrimidinyl and pyrazinyl are each optionally substituted with one to three substituents independently selected from R6 ''; (f) R6 '' is independently selected from CF 3, C 1 -C 4 alkyl, halo, hydroxy (C 1-C 3) alkyl, C 1-C 3 alkoxy and -C (O) CH 3; (g) R7 and R8 are each independently selected from hydrogen, (C1-C6) alkyl and trifluoromethyl; (h) R9 and R10 are each independently selected from hydrogen, (C 1 -C 4) alkyl, (C 1-C 3) alkenyl, halo and (C1-C4) alkoxy; (i) T 1 is N or C; (j) Q is selected from a single link and C; (k) W is selected from O and S, (l) X is C mH 2m; (m) m is selected from 0, 1 and 2; (n) Y and Z are each independently selected from N, S and O, with the proviso that at least one of Y and z is selected from S and O; (o) A is COOH; with the proviso that when R3 and R4 are each hydrogen and at least one selected from R7 and R8 is CF3, R5 is selected from alkyl (C3-C6), alkenyl (C1-C6), arylalkyl (C0-C4) ) substituted, substituted (C0-C4) alkyl aryloxy, substituted (C0-C4) alkylthyl, unsubstituted (C0-C4) arylalkyl, unsubstituted (C0-C4) alkyl aryloxy and unsubstituted (C0-C4) alkyl. |