http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2316486-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a7f82940e47ba7a1188f8e2ffca55e0f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4535 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4545 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-497 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4418 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4523 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 |
| filingDate | 2001-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16b005c4d43db2235f8aa8102aa80e24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d77bf4c2727a530ee196b86b25d5518 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e493fb8f819558010c94991cc3c9da1e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a5fd2349d2e1a6c672cc205f4901f1e |
| publicationDate | 2009-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2316486-T3 |
| titleOfInvention | ANTAGONSITAS OF THE Y5 RECEPTORS OF THE NEUROPEPTIDE AND HETEROARIL-UREA. |
| abstract | A compound of the formula (I) ** see formula ** or one of its pharmaceutically acceptable salts and / or a hydrate of said compound, or, where applicable, a geometric or optical isomer or one of its racemic mixtures, wherein : = AB = is = C (R 4) -C (R 5) = and -X = Y- is -C (R 6) = N-, -N = C (R 7) -, -N = N- , or -S-, o = AB = is = NC (R 5) = and -X = Y- is -N = C (R 7) -, -C (R 6) = N-, -S- or - OR-; o = AB = is = C (R 4) -N = y -X = Y- is -C (R 6) = N-, -S- or -O-, or = AB = is = NN = y -X = Y- is -S- or -O-, or = AB = is = C (R 4) - and -X = Y- is -SN =, -NC (R 10) -N, or = AB = is = NC (R 4) = and -X = Y- is -NS-, or = NN (R 10) -; Z is ** see formula ** R1 is H or (C1-C6) alkyl; R 2 is H, (C 1-C 6) alkyl, (C 3-C 7) cycloalkyl or (C 1-C 6) alkyl (C 3-C 7) cycloalkyl; R 3 is ** see formula ** Q is -OR 13 or -NR 13 R 14; j is 1 or 2; k is 0, 1 or 2; i is 0, 1 or 2; m is 0, 1 or 2; R 4, R 3, R 6 and R 7, may be the same or different, and are independently selected from the group comprising H, -OH, halogen, polyhaloalkyl, -C1-C6 alkyl, cycloalkyl (C3-C7) , -C1-C6-alkyl-(C3-C7) cycloalkyl, -CN, NR 10 R 11, NR 13 R 14, -O-alkyl (C 1-C 6), -O-cycloalkyl (C 3-C 7), -O-(C 1-C 6) alkyl-(C 3-C 7) cycloalkyl, -S-(C 1-C 6) alkyl, -S-C (C 3-C 7) alkyl or -S -C1-C6 alkyl-cycloalkyl (C3-C7); R 8 is 1 to 3 substituents, which may be the same or different and are independently selected from the group consisting of H, halogen, -OH, polyhaloalkyl, polyhaloalkoxy, -CN-, -NO 2, -alkyl (C 1 -C 6) , - (C 3 -C 7) cycloalkyl, - (C 1-C 6) alkyl-(C 3-C 7) alkyl, NR 10 R 11, NR 13 R 14, -O-alkyl (C 1-C 6) ), -O-C 3 -C 7 -alkyl, -O-C 1 -C 6 -alkyl-C3-C7 -alkyl or -CONR 13 R 14; R 9 is -SO 2-(C 1-C 6) alkyl, -SO 2-cycloalkyl (C 3-C 7), -SO 2-alkyl (C 1-C 6) -cycloalkyl (C 3-C 7) , -SO 2-polyhaloalkyl (C 1-C 6), -SO 2- [hydroxy-alkyl (C 2-C 6)], -SO 2- [amino-alkyl (C 1-C 6)], -SO 2- [C 1 -C 6 -alkoxy], -SO2- [C2-C6-alkylamino], -SO2- [C2-C6-dialkylamino-alkyl], -SO2- (aryl), -SO2- (heteroaryl), -SO2- [aryl-C1-C6 alkyl], -SO2NR 13 R 14, -CO ((C1-C6) alkyl, -CO-cycloalkyl (C3-C7), -CO- (C1-C6) alkyl (C3-C7) cycloalkyl, CO-(C1-C6) -cycloalkyl (C3-C7), CO-polyhaloalkyl (C1-C6), -C (O) aryl, -C (O) heteroaryl, -CONR 13 R 14, -C (S) NR 13 R 14, aryl, heteroaryl, - (CH 2) CONR 13 R 14, -C (= NCN) alkylthio, -C (= NCN) NR 13 R 14 , (C 1 -C 6) alkyl, (C 3-C 7) cycloalkyl, (C 1-C 6) alkyl (C 3-C 7) cycloalkyl, (C 1-C 6) alkyl, aryl, -C1-C6 alkyl heteroaryl or -COCO 12; R 10 is H or alkyl; R 11 is H, (C1-C6) alkyl, C3-C7 cycloalkyl, -C1-C6 alkyl-C3-alkyl -C7), aryl, heteroaryl, -SO2-(C1-C6) alkyl, -SO2-(C3-C7) cycloalkyl, -SO2-(C1-C6) alkyl-(C3-C7) cycloalkyl, -SO2-polyhaloalkyl (C1-C6), -SO 2 (aryl), -SO 2 (heteroaryl), -CO-(C 1-) alkyl C 6), -CO-cycloalkyl (C 3-C 7), -CO-alkyl (C 1-C 6) -cycloalkyl (C 3-C 7), -C (O) aryl, -C (O) heteroaryl , -CONR 13 R 14 or -COOR 12; R 12 is (C1-C6) alkyl, (C3-C7) cycloalkyl, (C1-C6) alkyl-(C3-C7) cycloalkyl, (C1-C6) alkyl, -aryl, (C1-C6) alkyl heteroaryl, aryl or heteroaryl; R 13 and R 14 may be the same or different, and are independently selected from the group consisting of H, (C 1 -C 6) alkyl, (C 3 -C 7) alkyl, (C 1 -C 6) alkyl (C 3-C 7) alkyl , -C1-C6 alkyl-aryl, aryl or heteroaryl; and R 15 is one or two substituents that may be the same as different, and are independently selected from H, (C1-C6) alkyl, (C3-C7) alkyl, (C1-C6) alkyl (C3-C7) alkyl ), aryl, heteroaryl, CN, -CONR 13 R 14, -COOR 13, -OH, -O-alkyl (C 1-C 6), -O-cycloalkyl (C 3-C 7), -O-alkyl ( C 1-C 6) -cycloalkyl (C 3-C 7), -NR 10 R 11, -NR 13 R 14, or a (C 1-C 6) alkyl group substituted with an aryl, heteroaryl, alkoxy group, - NR 10 R 11 -NR 13 R 14, -CONR 13 R 14 or COOR 13, with the proviso that replacement with R 13 results in a stable compound. |
| priorityDate | 2000-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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