| abstract |
THE PRESENT INVENTION DESCRIBES A SECRETION POLIPEPTIDE, DESIGNATED OSTEOPROTEGERIN (OPG), WHICH IS A MEMBER OF THE RECEPTORS SUPERFAMILY OF THE TUMOR NECROSIS FACTOR, AND IS INVOLVED IN THE REGULATION OF THE OSEO METABOLISM. Also, NUCLEIC ACIDS DESCRIBING FOR OSTEOPROTEGERIN (OPG), POLYPEPTIDES, RECOMBINATING VECTORS AND CELLS GUESTED FOR EXPRESSION ARE DESCRIBED; ANTIBODIES THAT JOIN OPG, AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN IT. SUCH POLYPEPTIDES, ARE USED TO TREAT BONE DISEASES CHARACTERIZED BY AN INCREASED RESORTION, LIKE OSTEOPOROSIS. |