| abstract |
A compound of the formula I, (See formula) in which the meanings are: R 1 phenyl, pyridyl, thienyl, naphthyl, quinolinyl, pyrimidinyl or pyrazinyl, where each of these aryl radicals is unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CN, alkoxy having 1, 2, 3 or 4 carbon atoms, OCF3, methylsulfonyl, CF3, alkyl having 1, 2, 3 or 4 atoms carbon, dimethylamino, sulfamoyl, acetyl and methylsulfonylamino; R2 phenyl, pyridyl, thienyl, naphthyl, quinolinyl, pyrimidinyl or pyrazinyl, where each of these aryl radicals is unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CN , COOMe, CONH2, alkoxy having 1, 2, 3 or 4 carbon atoms, OCF3, OH, methylsulfonyl, CF3, alkyl having 1, 2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, acetyl and methylsulfonylamino; R3 CpH2p-R7; p 0, 1, 2, 3, 4 or 5; R7 CH3, CH2F, CHF2, CF3, cycloalkyl having 3, 4, 5, 6 or 7 carbon atoms, C equiv CH, C equiv C-CH3, alkoxy having 1, 2, 3 or 4 carbon atoms, phenyl or 2-pyridyl, where the phenyl and 2-pyridyl groups are unsubstituted or substituted with 1, 2 or 3 substituents selected from the group consisting of F, Cl, Br, I, CF3, OCF3, CN, COOMe, CONH2, COMe, OH, alkyl having 1, 2, 3 or 4 carbon atoms, alkoxy having 1, 2, 3 or 4 carbon atoms, dimethylamino, sulfamoyl, methylsulfonyl and methylsulfonylamino; R4 hydrogen or alkyl having 1, 2 or 3 carbon atoms; R5 hydrogen or alkyl having 1, 2 or 3 carbon atoms; R6 hydrogen, F, Cl, CF3 or alkyl having 1, 2 or 3 carbon atoms; X CH or N; and pharmaceutically acceptable salts and trifluoroacetates thereof. |