http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2315398-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_331acb2d2e4707f43b8f6c3cf6f79ab2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-90 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-01 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-90 |
| filingDate | 2002-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4865b77b048215fe3ecddd66832ed23a |
| publicationDate | 2009-04-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2315398-T3 |
| titleOfInvention | DERIVATIVES OF 4 '' - DESOXI-4 '' - (S) -AMINO AVERMECTINA. |
| abstract | Compound of formula (See formula) that in position 4 "has the configuration (S) and in which R1 is C1-C12 alkyl, C3-C8 cycloalkyl; or C2-C12 alkenyl; R2 is C1-8 alkyl; R3 is C1-C12 alkyl, C1-C12 alkyl mono- to pentasubstituted, C1-C12 alkoxy-C1-C12 alkyl unsubstituted or mono- to pentasubstituted, C3-C12 cycloalkyl unsubstituted or mono- to pentasubstituted; C2-C12 alkenyl unsubstituted or mono- to penta substituted; unsubstituted C4-C12 cycloalkenyl or mono- to penta substituted; unsubstituted C2-C12 alkynyl or mono-to penta substituted; or R2 and R3 together are a three to seven membered alkylene bridge or a four to alkenylene bridge seven members, in each of which a CH2 group may be substituted by O, S or NR4; wherein the substituents of the aforementioned alkyl, alkoxy-alkyl, alkenyl, alkynyl, alkylene, alkenylene, cycloalkyl and cycloalkenyl radicals are selected from the group consisting of OH, halogen, halo-C1-C2 alkyl, CN, SCN, NO2, Si (al C 1 -C 12 chyl) 3, C 2 -C 6 alkynyl, C 3 -C 8 cycloalkyl which is unsubstituted or substituted by one to three methyl groups, norbornylenyl, C 3 -C 8 cycloalkenyl which is unsubstituted or is substituted by one to three methyl groups; C3-C8 halocycloalkyl, C1-C12 alkoxy, C1-C6 alkoxy-C1-C6 alkoxy, C3-C8 cycloalkoxy, C1-C12 haloalkoxy, C1-C12 alkylthio, C3-C8 cycloalkylthio, C1-C12 haloalkyl, C1-C12 alkylsulfinyl, C3-C8-sulfinyl cycloalkyl, C1-C12-sulfinyl haloalkyl, C3-C8-sulfinylcycloalkyl, C1-C12 alkyl-sulfonyl, C3-C8-sulfonyl cycloalkyl, C1-C12 haloalkyl-sulfonyl, C3-C8-sulfonyl, alkenyl C2-C8, C2-C8 alkynyl, NH2, NH (C1-C6 alkyl), NH (hydroxy-C1-C6 alkyl), N (C1-C6 alkyl) (hydroxy-C1-C6 alkyl), N (phenyl) ( hydroxy-C1-C6 alkyl), N (C1-C6 alkyl) 2, -C (= X) ZR5, -OC (= X) R6, -OC (= X) N (R8) R6, -NHC (= X ) R6, -NHC (= X) OR6, -NHC (= X) SR6, -NHC (= X) N (R8) R6, -SC (= S) R6, -NHS (O) 2-R9, -P (= O) (O-C1-C6 alkyl) 2; aryl, heterocyclyl, aryloxy, arylthio, heterocyclyloxy; and aryl, heterocyclyl, aryloxy, arylthio and heterocyclyloxy which, depending on the possibilities of substitution in the ring, are mono- to pentas substituted by substituents selected from the group consisting of OH, = O, halogen, CN, NO2, C1-C12 alkyl , C1-C12 hydroxyalkyl, C3-C8 cycloalkyl, C1-C12 haloalkyl, C1-C12 alkoxy, C1-C12 haloalkoxy, C1-C12-thio alkyl, C1-C12-thio haloalkyl, C1-C6 alkoxy-C1-C6 alkyl, C1-C6 dimethylaminoalkoxy, C2-C8 alkenyl, C2-C8 alkynyl, Si (C1-C12 alkyl) 3, methylenedioxy, -C (= X) R5, -OC (= X) R6, -CH2-C (= O) R5, -CH2-OC (= O) R6, -NH-C (= X) R6, -SC (= S) R6, NH2, NH (C1-C2 alkyl), -N (C1-C12 alkyl) 2, C1-C6 alkyl sulphinyl, C3-C8-sulfinyl cycloalkyl, C1-C6-sulfinyl haloalkyl, C3-C8 alkylcycloalkyl sulfinyl, C1-C6-alkyl sulfonyl, C3-C8 cycloalkyl sulfonyl, haloC1-C6-sulfonyl and C3 halocycloalkyl -C8-sulfonyl; phenyl, phenoxy, C1-C6 phenylalkyl, C1-C6 phenyl-alkoxy, C2-C6 phenyl-alkenyl, unsubstituted C2-C6 alkynyl; phenyl, phenoxy, phenyl-C1-C6 alkyl, phenyl-C1-C6 alkoxy, phenyl-C2-C6 alkenyl and phenyl-C2-C6 alkynyl, each of which is substituted on the phenyl ring by one to three selected substituents independently from each other of nitro, cyano, halogen, C1-C12 alkoxy, halo C1-C12 alkyl and halo C1-C12 alkoxy; X is O or S; Z is a link, OR NR8 or S; R4 is C1-C8 alkyl, C3-C8 cycloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, benzyl or -C (= O) -R5; R5 is H, OH, SH, C1-C12 alkyl, C2-C8 alkenyl, C2-C8 alkynyl, C1-C12 haloalkyl, C2-C8 haloalkenyl, C1-C6 alkoxy-C1-C6 alkyl, -C1-C6S (O ) 2-R9, C1-C6 alkyl which is mono- or disubstituted with substituents selected from COOH, -C (= O) O-CH2-phenyl, unsubstituted or substituted phenyl, unsubstituted or substituted biphenyl, where the substituents are selected between cyano, halogen, nitro, trifluoromethyl, and benzyloxy; aryl, heterocyclyl, C1-C12 arylalkyl, aryloxy-C1-C12 alkyl, -C1-C6-C alkyl (= O) -R7; or aryl, heterocyclyl, C1-C12 arylalkyl, aryloxy-C1-C12 alkyl, each of which is substituted on the aromatic ring by one to three substituents independently selected from each other of halogen, nitro, cyano, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy; R6 is H, C1-C24 alkyl, C1-C6 alkoxy-C1-C6 alkyl, hydroxy C1-C12 alkyl, C1-C12 haloalkyl, C2-C8 alkenyl, C2-C8 alkynyl, C3-C8 cycloalkyl, -C1-C6S (O ) 2-R9, aryl or phenyl-C1-C6 alkyl; wherein the phenyl and aryl radicals may carry from one to three substituents independently selected from each other of nitro, cyano, halogen, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy; R7 is H, OH, C1-C12 alkyl, C1-C12 alkoxy, C1-C6 alkoxy-C1-C8 alkoxy, C2-C8-oxy alkenyl, phenyl, phenoxy, benzyloxy, NH2, NH (C1-C12 alkyl), N (C1-C12 alkyl) 2, -NH-phenyl or -N (C1-C12 alkyl) -phenyl; R8 is H, C1-C12 alkyl, phenyl or bezyl; and R9 is H, C1-C12 alkyl, aryl, C1-C12 arylalkyl, or aryl or C1-C12 arylalkyl, where the aryl radical can carry one to three substituents independently selected from each other of nitro, cyano, halogen, C1- alkyl C6, C1-C6 alkoxy, C1-C6 haloalkyl and C1-C6 haloalkoxy; and, when appropriate, E / Z isomers, mixtures of E / Z isomers and / or tautomers thereof, in each case in free form or in salt form. |
| priorityDate | 2001-08-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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