| abstract |
A compound of Formula I: (See formula) in which: A is selected from the group consisting of (See formulas) R is H, halo, -COOH or -CH2COOH; R 1 is phenyl optionally substituted with a first substituent selected from the group consisting of halo, cyano, C1-C4 acyl, -COOH, -NHR 3, C1-C2 alkyl substituted with -NHCH3, -N (SO2 (C1-C3 alkyl )) 2, -COOH, -CONH2, cyano, hydroxy or tetrazol-5-yl, -OCH2COOH, -SCH2COOH, -C (O) CH2CH2COOH, -SO2NH2, tetrazol-5- yl and 1,2,4-triazole- 1-yl; optionally further substituted with a second substituent selected from the group consisting of: halo, trifluoromethyl, cyano, nitro, C1-C4 alkoxy, hydroxy, C1-C4 alkyl, C1-C4 alkylthio, -NHCH2CN, -OCH2CN, -NHSO2CH (CH3) 2, and C (O) NHR 4; optionally further substituted with a third substituent selected from the group consisting of halo and cyano; optionally further substituted with a fourth substituent selected from the group consisting of halo; R 2 is C1-C4 alkyl or dimethylamino; R 3 is -SO2 (C1-C3 alkyl), C1-C4 acyl, C1-C4 alkyl, or hydrogen; R 4 is hydrogen, C1-C4 alkyl, or -SO2 (C1-C4 alkyl); or a pharmaceutically acceptable salt thereof. |