| abstract |
Compounds of the formula (I) (See formula) where n is an integer selected from 0 to 3; R 1 is independently selected from the group containing halogen, -CN, -NO2, -SO2Me, lower alkyl, trifluoromethoxy, -OR 11, piperidinyl, pyrrolidinyl, and -N (R 11) (R 11), where R 11 is independently selected from lower alkyl and H, X 1, X 2, X 3, and X 4 are independently selected from nitrogen and carbon, provided that no more than two of X 1, X 2, X 3, and X 4 are nitrogen at the time, and when two of X 1, X 2, X 3, and X 4 are nitrogen, n is 0, 1, or 2; k is an integer from 0 to 1; R 2 is H; R 3 is H, alkyl, or halogen; R 4 is aryl, heteroaryl, alkylaryl or alkylheteroaryl, all being optionally substituted with one to five substituents selected from the group containing halogen, alkyl, -OR 41, C2-C7 alkynyl, and NR 42 R 43, wherein R 41 is alkyl C1-C6 or -H, R 42 and R 43 independently of each are hydrogen or alkyl, or NR 42 R 43 is piperidinyl or pyrrolidinyl, or R 4 is alkyl; R 5 is ... |