http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2314272-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd47318319f20f7f99d9fef1fd3e511b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57434 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N- http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate | 2003-12-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1371cfd4eb071a22751551d0be8f9323 |
| publicationDate | 2009-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2314272-T3 |
| titleOfInvention | METHODS FOR DIAGNOSIS AND TREATMENT OF CANCER. |
| abstract | A compound represented by the structural formula: (See formula) or a pharmaceutically acceptable salt or solvate thereof, in which: X is CH or N; Y is selected from the group consisting of C, CH or N, and when Y is CH or N, the optional covalent bond (represented by the dotted line between rings II and IV) is absent, and when Y is C, it is present that optional covalent bond; G is (CHR 4) n or C (= O); R is selected from the group consisting of unsubstituted alkyl, alkyl substituted with a heterocyclyl, -N (R 4) 2 where the two R 4 moieties may be the same or different, and -OR 4, where said heterocyclyl may not be substituted or be optionally substituted with one or more moieties that may be the same or different, each being independently selected from the group consisting of alkyl, aryl, -OR 4, -N (R 4) 2 where the two R 4 moieties may be same or different, -C (O) R 4 and -C (O) N (R 4) 2 where the two R 4 moieties may be the same or different; the position a of ring I is N or N + O-, and the remaining positions b, c and d represent C (R 1) or C (R 2); R 1 and R 2 may be the same or different, each being independently selected from the group consisting of: H, halo, -CF3, -OR 4, -C (O) R 4, -OCF 3, -SR 4 , -S (O) nR 5, benzotriazol-1-yloxy, tetrazol-5-ylthio, alkynyl, alkenyl, wherein said alkenyl may be unsubstituted or optionally substituted with halo, -OR 4 or -C (O) OR 4, alkyl, wherein said alkyl may be unsubstituted or optionally substituted with halo, -OR 4 or -C (O) OR 4, -N (R 4) 2, where the two R 4 moieties may be the same or different, -NO2, -OC (O) R 5, -C (O) OR 4, -CN, -N (R 4) C (O) OR 4, -SR 5 C (O) OR 4 and -SR 5 N (R 4) 2 (provided that R 5 in -SR 5 N (R 4) 2 is not -CH2-), where each R 4 is independently selected; the dotted line between carbon atoms 5 and 6 represents an optional bond, such that when a double bond is present, A and B can be the same or different, each being independently selected from the group consisting of - R 4, halo, -OR 4, -C (O) OR 4, -OC (O) OR 4 or -OC (O) R 4, and when a double bond between carbon atoms 5 and 6 is not present, A and B may be the same or different, each being independently selected from the group consisting of (H2), - (OR 5) 2, (H and halo), (dihalo), (H and R 5), ( R 5) 2, (H and -OC (O) R 4), (H and -OR 4), (= O) and (H, (= NOR 4) or (-O- (CH2) pO-) where p is 2, 3 or 4); R 3 is selected from the group consisting of H, alkyl, alkoxy and alkoxyalkyl; R 4 is selected from the group consisting of H, alkyl, aryl and aralkyl; R 5 is alkyl or aryl; R 6 is H or alkyl; n is a number from 1 to 4; q is a number from 1 to 8; and in which the alkyl contains 1 to 20 carbon atoms in the chain; aryl contains from 6 to 14 carbon atoms; the heteroaryl contains from 5 to 14 ring atoms; the cycloalkyl contains 3 to 10 carbon atoms and the heterocyclyl contains 3 to 10 ring atoms. |
| priorityDate | 2003-01-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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