| abstract |
A compound of Formula I: (See formula) in which: A is: alkyl., Cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl, heterocycloalkyl, nucleoside, amino acid, di-, tri- or tetra-peptide, -CH2 -C (O) -C (O) -O-R '' or -CH = C (OH) -C (O) -O-R ''; X is: -N (R '') -, -S-, -S (O) -, -S (O) 2-, -SYS-, or a covalent bond with the sulfur atom of Cys or with the atom of heterocyclyl nitrogen; Y is: aryl, heteroaryl, nucleoside, an amino acid, or a di-, tri- or tetra-peptide; W is: = O, = N-OR a, = N-NR b R c, or -N (OH) -R d; Z is: -OR, -SR, or -NR b R c; R '' is: independently selected from hydrogen, alkyl, cycloalkyl or aryl; R is: hydrogen, alkyl, cycloalkyl, aryl, aralkyl, heteroaryl, heteroaralkyl, heterocyclyl or heterocycloalkyl; R a is: hydrogen, alkyl, aryl, aralkyl, or alkenyl; R b is independently selected from hydrogen, alkyl, aryl, aralkyl or cycloalkyl; R c is: independently selected from hydrogen or alkyl; and R d is: hydrogen, acyl or alkyl; or R by R c together with the nitrogen to which they are attached can form a 5- to 7-membered ring, optionally incorporating one or two additional heteroatoms to the ring chosen from N, S, or O, and said ring being optionally substituted with one or more substituents independently selected from the group consisting of = O, = S, acyl, alkenyl, alkyl, (alkoxy) carbonyl, and (amino) carbonyl; including simple tautomers, simple stereoisomers, and mixtures of tautomers and / or stereoisomers, and their pharmaceutically acceptable salts, with the proviso that when X is -S-, W is = O, and Z is OH, A is not 6-amino -3,5-dicyano-4-phenyl-pyridin-2-yl. for use in the treatment of a mammal having a condition characterized by oxidative stress, in which the compound is used in a therapeutically effective amount. |