http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2313908-T3
Outgoing Links
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9871e02d1c09cc338f51aecbb5510178 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-92 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-76 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-74 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2863 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-13 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P17-02 |
filingDate | 2000-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2009-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86b8c696b670254b023fa8c87063c1ba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9ae7e8f2f081e44f53c1333159786188 |
publicationDate | 2009-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | ES-2313908-T3 |
titleOfInvention | HUMAN MONOCLONAL ANTIBODIES AGAINST THE TGF-BETA II RECEIVER AND ITS MEDICINAL USE. |
abstract | A monoclonal human antibody or F (ab '') 2, Fab '', Fab, Fv, sFv, dsFv or dAb antigen binding fragment, wherein the antibody or antigen binding fragment suppresses cell growth induced by TGF-Beta, wherein (a) a heavy chain variable region comprises the amino acid sequence of residues 21 to 117 of SEQ ID NO: 4 and a light chain variable region the amino acid sequence of residues 23 to 117 of SEQ ID NO: 12; (b) a heavy chain variable region comprises the amino acid sequence of residues 21 to 117 of SEQ ID NO: 4, wherein 1 to 10 amino acids have been deleted, substituted, inserted or added, and a variable light chain region the amino acid sequence of residues 23 to 117 of SEQ ID NO: 12, wherein 1 to 10 amino acids have been deleted, substituted, inserted or added; (c) a heavy chain variable region comprises the amino acid sequence of residues 2 to 98 of SEQ ID NO: 6 and a light chain variable region the amino acid sequence of residues 21 to 116 of SEQ ID NO: 14; (d) a heavy chain variable region comprises the amino acid sequence of residues 2 to 98 of SEQ ID NO: 6, wherein 1 to 10 amino acids have been deleted, substituted, inserted, or added, and a variable chain region lightly the amino acid sequence of residues 21 to 116 of SEQ ID NO: 14, wherein 1 to 10 amino acids have been deleted, substituted, inserted or added; (e) a heavy chain variable region comprises the amino acid sequence of residues 21 to 116 of SEQ ID NO: 8 and a light chain variable region the amino acid sequence of residues 22 to 120 of SEQ ID NO: 16; (f) a heavy chain variable region comprises the amino acid sequence of residues 21 to 116 of SEQ ID NO: 8, wherein 1 to 10 amino acids have been deleted, substituted, inserted, or added, and a variable chain region lightly the amino acid sequence of residues 22 to 120 of SEQ ID NO: 16, wherein 1 to 10 amino acids have been deleted, substituted, inserted, or added; (g) a heavy chain variable region comprises the amino acid sequence of residues 21 to 117 of SEQ ID NO: 10 and a light chain variable region the amino acid sequence of residues 18 to 113 of SEQ ID NO: 18; or (h) a heavy chain variable region comprises the amino acid sequence of residues 21 to 117 of SEQ ID NO: 10, wherein 1 to 10 amino acids have been deleted, substituted, inserted, or added, and a variable region of Light chain the amino acid sequence of residues 18 to 113 of SEQ ID NO: 18, wherein 1 to 10 amino acids have been deleted, substituted, inserted or added. |
priorityDate | 1999-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1483.