http://rdf.ncbi.nlm.nih.gov/pubchem/patent/ES-2313401-T3
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d28722ea47feca3df8aff6cabb7f7cf7 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C2601-04 |
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| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-198 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-341 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-69 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4406 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-36 |
| filingDate | 2005-07-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2009-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37c7e5b65e23e081493109cac0db7d42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_325f428d0899aa4d7fd166fb179491d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d767345a5abb2394a82a07b3a46e49e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4bbd318fa92cd83c516ace8c277f9f7d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f4d1e6f39c2470605c1b09589dc94ac4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f953ea3092926deba546f422792c50f |
| publicationDate | 2009-03-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | ES-2313401-T3 |
| titleOfInvention | THYROSINE DERIVATIVES AS MODULATORS OF PPAR-GAMMA. |
| abstract | Compound of formula I (See formula) its stereoisomers and mixtures thereof, its polymorphs and mixtures thereof, and the pharmaceutically acceptable solvates and addition salts thereof, in which: R1 represents the 2-benzoylphenylamino radical; R2 represents - (C2) s-N (COR3) -A-J-T or - (C2) s-N (R4) -B-J-T; R3 represents -C1-C10 alkyl optionally substituted with one or more substituents selected from -F, -Cl, -Br and -O-(C1-C4) alkyl; -alkenyl (C2-C6); -alkynyl (C2-C6); -alkyl (C1-C3) -I; -alkenylene (C2-C3) -I; -alkinylene (C2-C3) -I or -I; R4 represents -C4-C10 alkyl optionally substituted with one or more substituents selected from -F, -Cl, -Br and -O-(C1-C4) alkyl; -alkyl (C2-C6), -alkynyl (C2-C6); -alkyl (C1-C4) -I; -alkenylene (C2-C4) -I; -alkinylene (C2-C4) -I or -I; s represents 2 or 3; A represents -alkylene (C1-C4) -; -alkenylene (C2-C4) -; -alkinylene (C2-C4) -; -alkylene (C1-C4) -Z-, in which the alkylene part is attached to the atom of N and Z is attached to J; or -Z-; B represents -alkylene (C4) -; -alkenylene (C2-C4) -; -alkinylene (C2-C4) -; -alkylene (C1-C4) -Z-, in which the alkylene part is attached to the atom of N and Z is attached to J; or -Z-; J represents a single bond or a birradical selected from the following groups: a) - (C2) 1 - 4-, -O-, -S-, -SO-, -SO2-, -CO-, -OCO-, - COO-, -OCONR5-, -NR5COO-, -CONR5-, -NR5CO-, -NR5-, -NR5SO2-, -SO2NR5-, and b) -O-alkyl (C1-C4) -, -alkyl (C1-C4 ) -O-, -S-(C1-C4) alkyl -, -alkyl (C1-C4) -S-, -SO-alkyl (C1-C4) -, -alkyl (C1-C4) - SO-, - SO2-C1-C4 alkyl -, -C1-C4 alkyl -SO2-, -OCO-C1-C4 alkyl -, -COO-C1-C4 alkyl -, -C1-C4 alkyl -OCO-, -C1-C4 alkyl -COO-, -OCONR5-C1-C4-alkyl-, -NR5COO-C1-C4-alkyl-, -C1-C4 alkyl -OCONR5-, -alkyl (C1-C4) -NR5COO-, -CONR5-alkyl (C1-C4) -, -NR5CO-alkyl (C1-C4) -, -alkyl (C1-C4) -CONR5-, -alkyl (C1-C4) - NR5CO-, -NR5-alkyl (C1-C4) -, -alkyl (C1-C4) -NR5-, -SO2NR5-alkyl (C1-C4) -, -NR5SO2-alkyl (C1-C4) -, -alkyl ( C1-C4) -SO2NR5-, -C1-C4 alkyl -NR5SO2-; T represents -H, -C1-C4 alkyl, -C2-C4-alkenyl, -C2-C4 -alkynyl, or -I; I represents a monorax from a cycle selected from a cycloalkane (C3-C6), cyclohexene, a heterocycle, benzene and a bicyclo, in which all these cycles can be optionally substituted with one or more substituents selected from the group -OH, - CO, -SH, -NO2, -CN, -F, -Cl, -Br, -CO-C1-C4 alkyl, -COO-C1-C4 alkyl, -OCO-C1-C4 alkyl, -S-C1-C4 alkyl, -SO-C1-C4 alkyl, -SO2-C1-C4 alkyl, -SO2-O-C1-C4 alkyl, -O-SO2-C1-alkyl -C4), -NR5R6, -CONR5R6, -C1-C4 alkyl optionally substituted with one or more -OH or -F and -O-C1-C4-alkyl optionally substituted with one or more -OH or -F, and wherein the cycloalkane (C3-C6), cyclohexene and bicyclo cycles may also be optionally substituted with one or more oxo substituents; Z represents a biradical from a cycle selected from a cycloalkane (C3-C6), cyclohexene, a heterocycle, benzene and a bicyclo, in which all these cycles may be optionally substituted with one or more substituents selected from the group -OH, - CO, -SH, -NO2, -CN, -F, -Cl, -Br, -CO-C1-C4 alkyl, -COO-C1-C4 alkyl, -OCO-C1-C4 alkyl, -S-C1-C4 alkyl, -SO-C1-C4 alkyl, -SO2-C1-C4 alkyl, -SO2-O-C1-C4 alkyl, -O-SO2-C1-alkyl -C4), -NR5R6, -CONR5R6, -C1-C4 alkyl optionally substituted with one or more -OH or -F and -O-C1-C4-alkyl optionally substituted with one or more -OH or -F, and wherein the cycloalkane (C3-C6), cyclohexene and bicyclo cycles may also be optionally substituted with one or more oxo substituents; R5 and R6 independently represent -H or -C1-C4 alkyl; a heterocycle in the above definitions represents a five or six membered aromatic ring containing from one to three heteroatoms independently selected from O, S and N, wherein said ring can be attached to the rest of the molecule through an atom of carbon or one of nitrogen; and a bicyclo in the above definitions represents a partially unsaturated, saturated or aromatic seven to ten-membered ring that optionally contains from one to three heteroatoms independently selected from O, S and N, wherein said ring or rings may (n) be bound (s) to the rest of the molecule through a carbon or a nitrogen atom. |
| priorityDate | 2004-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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