| abstract |
Compounds of the formula (See formula) wherein R 1 is C 1-8 aryl or C 3-8 heteroaryl; R 2 is hydrogen, alkyl or cycloalkyl; R 3 is alkoxy or C1-8 alkoxy substituted with one to three halogen atoms; R 4 is hydrogen, C 1-8 alkyl or C 3-8 cycloalkyl; A is oxygen or sulfur; n is 1, 2 or 3; and, wherein the bond between carbon atoms C a and C b is a double or single carbon carbon bond; and pharmaceutically acceptable salts and esters thereof; wherein the term "aryl" means a phenyl or naphthyl group that optionally comprises one or more substituents each independently selected from halogen, trifluoromethyl, amino, C1-8 alkyl, C1-8 alkoxy, C1-8 alkylcarbonyl, cyano, carbamoyl, C 1-8 alkoxycarbamoyl, methylenedioxy, carboxy, C 1-8 alkoxycarbonyl, aminocarbonyl, C 1-8 alkylaminocarbonyl, di-C 1-8 alkylaminocarbonyl, hydroxy, C 1-8 alkyl, substituted with one to three halogen atoms, nitro; and wherein the term "heteroaryl" means 5 to 10 membered aromatic heterocycle containing one or more heteroatoms chosen from nitrogen, oxygen and sulfur, whose heteroaryl may be substituted on one or more carbon atoms by halogen, C1-8 alkyl, C1-8 alkoxy, cyano, halo-C1-8 alkyl and / or trifluoromethyl. |