| abstract |
A compound represented by the structural formula (See formula) or a pharmaceutically acceptable salt or solvate of said compound, isomer or racemic mixture, wherein: Ar 1 is C6-14 aryl, heteroaryl comprising 5-14 ring atoms, C6 aryl - 14 substituted with (R 7) or heteroaryl substituted with (R 7) p comprising 5-14 ring atoms, where p is a number from 1 to 3 and when p is greater than 1, each R 7 can be the same or different and is independently selected from the group consisting of C1-20 alkyl, C3-10 cycloalkyl, halo, -CN, C1-20 alkoxy, -CF3, -OCF3, -C (O) N (R 8) 2, -N (R 9) 2, (C1-C6) alkylene N (R 9) 2 -S-C1-20 alkyl, -S (O) -C1-20 alkyl, -S (O2) -C1-20 alkyl, -S (O2) N (R 8) 2, -N (R 8) C (O) R 5, (C1-C6) N (R 8) C (O) R 5, NO2, -C (O) alkyl C1-20, C (O2) R 8, C (R 8) 2OR 8, C = NOR 8 and a cyclic moiety selected from the group consisting of: (See formula) where said cyclic moiety, together with Ar 1, can optionally form a remainder fused aromatic, such as indolone, benzimidazole, benzoxazole, benzothiazole, benzoisoxazole or benzotriazole; and further wherein if two R 7 groups are adjacent, said adjacent R 7 moieties may be optionally linked to form a methylenedioxy or ethylenedioxy moiety, Ar 2 is C6-14 aryl, heteroaryl comprising 5-10 ring atoms, C6-14 aryl substituted with (R 7) or heteroaryl substituted with (R 7) p comprising 5-10 ring atoms, where p is an integer from 1 to 3 and when p is greater than 1, each R 7 can be the same or different and is independently selected from the group consisting of C1-20 alkyl, C3-10 cycloalkyl, halo, -CN, C1-20 alkoxy, -CF3, -OCF3, -C (O) N (R 8) 2, - N (R 9) 2, (C1-C6) alkylene -N (R 9) 2-S-C1-20 alkyl, -S (O) -C1-20 alkyl, -S (O2) -C1-20 alkyl, -S (O2) N (R 8) 2, -N (R 8) C (O) R 5, (C1-C6) N (R 8) C (O) R 5, NO2, -C (O) alkyl C1-20, C (O2) R 8, C (R 8) 2OR 8, C = NOR 8 and a cyclic moiety selected from the group consisting of: (See formula) where said cyclic moiety, together with Ar 2, can optionally form an aromatic residue fused tico, such as indolone, benzimidazole, benzoxazole, benzothiazole, benzoisoxazole or benzotriazole; and further wherein if two R 7 groups are adjacent, said adjacent R 7 moieties may be optionally linked to form a methylenedioxy or ethylenedioxy moiety, X is O, S or N- (CN); And it is... |