| abstract |
Method for screening for compounds, which are attached to a receptor of the EDb domain of fibronectin, comprising alpha2beta1-integrin, the method comprising: comparing a cell response in the presence of one or more of these compounds, with the response control of the aforementioned cells in the absence of these compounds, realizing that the cells - express proteins, which comprise the integrin alfa2beta1, realizing that the response or respectively the control response is mediated by this receptor of the fibronectin EDb domain, and realizing that the response or respectively the control response comprises the proliferation or adhesion of cells to surfaces, which are coated with the EDb domain of fibronectin or with parts thereof, and realizing that the cells are selected from endothelial cells, stromal cells of a tumor and tumor cells. |