| abstract |
A tetrahydro-naphthalene derivative of the formula (I), its tautomeric or stereoisomeric form, or a salt thereof (See formula) in which n represents an integer from 0 to 6; R 1 represents hydrogen or C 1-6 alkyl; R 2 and R 3, together with the nitrogen atom to which they are attached, form a 3-8 membered saturated heterocyclic ring optionally interrupted by one or two atoms selected from the group consisting of oxygen, sulfur and nitrogen, said saturated heterocyclic ring having optionally substituents selected from the group consisting of halogen, benzyl, hydroxy, amino, oxo and C 1-6 alkyl, or R 2 represents C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 alkyl substituted with amino, C 1-6 alkylamino, or di (C1-6 alkyl) amino; R 3 represents hydrogen, C 2-6 alkenyl, C 2-6 alkynyl, or C 1-6 alkyl substituted with amino, C 1-6 alkylamino, or di (C 1-6 alkyl) amino; and R 4 represents hydrogen, halogen, C 1-6 alkylthio, C 1-6 alkyl optionally substituted with mono-, di-, or tri-halogen, or C 1-6 alkoxy, optionally substituted with mono-, di-, or tri-halogen . |