| abstract |
Procedure for the preparation of (1E or 1Z) -oximities of 4- (3-oxo-estra-4,9-dien-11beta-yl substituted with 17alpha-methyl) -benzaldehyde of the general formula (I) (See formula) wherein R1 is a hydrogen atom, a C1-6 alkyl radical or a CnF2n + 1 radical, where n is 1, 2 or 3, R2 is a C1-4 alkyl radical or a trifluoromethyl group, X is a group OH located in position E or Z, and Y is a C1-6 O-alkyl group, a C1-6 S-alkyl group or an OCH2CnF2n + 1 group, being n 1, 2 or 3, characterized in that the 3, 3-dimethoxy-estra-5 (10), 9 (11) -dien-17-one of the formula (IX) (See formula) in which R2 has the meaning given above, is transformed with a reagent that it has active methylene, within an inert solvent, in the spiro-epoxide of the formula (X) (See formula) in which R2 has the meaning ... |