| abstract |
An immunogenic complex comprising a negatively charged organic complex and a charged antigen, whose organic complex and antigen are electrostatically associated, wherein the organic complex is a negatively charged adjuvant and comprises a saponin and a cholesterol and wherein the charged antigen comprises (i) one or more immunogenic polypeptides from a Hepatitis C Virus (HCV) region selected from Core, NS3, NS4a, NS4b, NS5a and NS5b, or (ii) a fusion protein comprising an immunogenic polypeptide a from the Core region of HCV and a second immunogenic polypeptide selected from regions E1, E2, NS3, NS4a, NS4b, NS5a and NS5b of HCV. |