| abstract |
A pharmaceutical formulation for oral or topical administration that includes: a) 0.1 to 30.0% of one or more hydrophobic active ingredients; b) 0.1 to 60.0% of one or more gelling agents selected from polyglycerin esters of fatty acids of the formula (1): CH2OR - CHOR - CH2O - [CH2 - CHOR - CH2O] nCH2 - CHOR - CH2OR (I ) where n is an integer from 4 to 13 and R is H or CO.R '' where R '' is saturated, unsaturated or hydroxylated C8-22 alkyl and where at least one group R is not hydrogen; having a HLB (lipophilic hydrophilic balance) value of not less than 10 c) 0.1 to 60.0% of one or more gel-forming substances selected from polyglyceryl esters of fatty acids and / or unsaturated fatty acids of formula ( 2) CH2OR - CHOR - CH2O - [CH2 - CHOR - CH2O] nCH2 - CHOR - CH2OR (2) where n is an integer from 0 to 10 and R is equal to H or CO.R '' where R '' is alkyl C8-22 saturated, unsaturated or hydroxylated and where at least one R group is not hydrogen, having a HLB value of not more than 9. d) 1.0 to 60.0% of one or more co-gelling substances selected between triglyceride esters of macrogol glycerin, partial glycerides of fatty acids or macrogol esters of fatty acids in which the average amount of ethylene oxide reacting in the synthesis of these substances varies between 50 and 150 moles and at the same time the relationship between components b) and d) is from 0.1: 1 to 10: 1; e) 5.0 to 30% of one or more C2 to C4 alcohols; where the previous percentages are selected over a total of 100%; and where, when diluted with water, the formulation forms a dispersion of polymorphic gel particles having a dimension of 0.2 to 500 mum. |